ID   AMP1_MESCR              Reviewed;          64 AA.
AC   O81338;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Antimicrobial peptide 1;
DE   Flags: Precursor;
OS   Mesembryanthemum crystallinum (Common ice plant) (Cryophytum crystallinum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   Caryophyllales; Aizoaceae; Mesembryanthemum;
OC   Mesembryanthemum subgen. Cryophytum.
OX   NCBI_TaxID=3544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Michalowski C.B., Bohnert H.J.;
RT   "Antimicrobial peptide 1 from the common ice plant.";
RL   Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Possesses antifungal and antibacterial activity.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the AMP family. {ECO:0000305}.
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DR   EMBL; AF069321; AAC19399.1; -; mRNA.
DR   PIR; T12305; T12305.
DR   AlphaFoldDB; O81338; -.
DR   SMR; O81338; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR   InterPro; IPR013006; Antimicrobial_C6_CS.
DR   InterPro; IPR009101; Gurmarin/antifun_pep.
DR   InterPro; IPR024206; Gurmarin/antimicrobial_peptd.
DR   Pfam; PF11410; Antifungal_pept; 1.
DR   SUPFAM; SSF57048; SSF57048; 1.
DR   PROSITE; PS60011; PLANT_C6_AMP; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Disulfide bond; Fungicide; Knottin;
KW   Plant defense; Secreted; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..64
FT                   /note="Antimicrobial peptide 1"
FT                   /id="PRO_0000001309"
FT   DISULFID        29..46
FT                   /evidence="ECO:0000250"
FT   DISULFID        36..50
FT                   /evidence="ECO:0000250"
FT   DISULFID        45..61
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   64 AA;  7005 MW;  D3B273B7A7017493 CRC64;
     MAKVSSSLLK FAIVLILVLS MSAIISAKCI KNGKGCREDQ GPPFCCSGFC YRQVGWARGY
     CKNR