ID   GL_PSHV1                Reviewed;         182 AA.
AC   Q6UDG5;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Envelope glycoprotein L {ECO:0000255|HAMAP-Rule:MF_04034};
DE            Short=gL {ECO:0000255|HAMAP-Rule:MF_04034};
DE   Flags: Precursor;
GN   Name=gL {ECO:0000255|HAMAP-Rule:MF_04034}; ORFNames=UL1;
OS   Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1)
OS   (Pacheco's disease virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Iltovirus.
OX   NCBI_TaxID=670426;
OH   NCBI_TaxID=152276; Amazona oratrix (yellow-headed parrot).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16873243; DOI=10.1128/jvi.00134-06;
RA   Thureen D.R., Keeler C.L. Jr.;
RT   "Psittacid herpesvirus 1 and infectious laryngotracheitis virus:
RT   Comparative genome sequence analysis of two avian alphaherpesviruses.";
RL   J. Virol. 80:7863-7872(2006).
CC   -!- FUNCTION: The heterodimer glycoprotein H-glycoprotein L is required for
CC       the fusion of viral and plasma membranes leading to virus entry into
CC       the host cell. Acts as a functional inhibitor of gH and maintains gH in
CC       an inhibited form. Upon binding to host integrins, gL dissociates from
CC       gH leading to activation of the viral fusion glycoproteins gB and gH.
CC       {ECO:0000255|HAMAP-Rule:MF_04034}.
CC   -!- SUBUNIT: Interacts with glycoprotein H (gH); this interaction is
CC       necessary for the correct processing and cell surface expression of gH.
CC       The heterodimer gH/gL seems to interact with gB trimers during fusion.
CC       {ECO:0000255|HAMAP-Rule:MF_04034}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000255|HAMAP-
CC       Rule:MF_04034}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_04034}; Extracellular side {ECO:0000255|HAMAP-Rule:MF_04034}.
CC       Host cell membrane {ECO:0000255|HAMAP-Rule:MF_04034}; Peripheral
CC       membrane protein {ECO:0000255|HAMAP-Rule:MF_04034}; Extracellular side
CC       {ECO:0000255|HAMAP-Rule:MF_04034}. Host Golgi apparatus, host trans-
CC       Golgi network {ECO:0000255|HAMAP-Rule:MF_04034}. Note=gL associates
CC       with the extravirion surface through its binding to gH. During virion
CC       morphogenesis, this protein probably accumulates in the host trans-
CC       Golgi where secondary envelopment occurs. {ECO:0000255|HAMAP-
CC       Rule:MF_04034}.
CC   -!- PTM: O-glycosylated, and sialylated.
CC   -!- SIMILARITY: Belongs to the herpesviridae glycoprotein L family.
CC       {ECO:0000255|HAMAP-Rule:MF_04034}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY372243; AAQ73745.1; -; Genomic_DNA.
DR   Proteomes; UP000006840; Genome.
DR   GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-UniRule.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0019064; P:fusion of virus membrane with host plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.390.170; -; 1.
DR   HAMAP; MF_04034; HSV_GL_alphagamma; 1.
DR   InterPro; IPR007923; Herpes_gL_N.
DR   InterPro; IPR038311; Herpes_gL_N_sf.
DR   InterPro; IPR034708; HSV_GL_alphagamma.
DR   Pfam; PF05259; Herpes_UL1; 1.
PE   3: Inferred from homology;
KW   Fusion of virus membrane with host cell membrane;
KW   Fusion of virus membrane with host membrane; Glycoprotein;
KW   Host cell membrane; Host Golgi apparatus; Host membrane; Membrane;
KW   Reference proteome; Signal; Viral envelope protein;
KW   Viral penetration into host cytoplasm; Virion; Virus entry into host cell.
FT   SIGNAL          1..39
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04034"
FT   CHAIN           40..182
FT                   /note="Envelope glycoprotein L"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04034"
FT                   /id="PRO_0000406815"
SQ   SEQUENCE   182 AA;  19354 MW;  A5B855F9D09C49F6 CRC64;
     MRRSAARGRA VSSTQTAMGA GAAIAVWAAA LIALYSSCAA QTAPKTSSLR AANASDTIGR
     LIDGAEQLVS MRCMTSFEHE AAVTLYGPEY TPGGSMFEDL LTIIFKPQCS PPEAILWYKS
     GTAVRVNPYY LCRILVLALQ GNPRGEVKFV VSRLIAEHAG GPLVRWPTTN VLRPEKTAPG
     GV