GMC2_YEAST
ID GMC2_YEAST Reviewed; 188 AA.
AC Q06201; D6VZ79;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 2.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Grand meiotic recombination cluster protein 2;
GN Name=GMC2; OrderedLocusNames=YLR445W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169871;
RA Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W.,
RA Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A.,
RA Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K.,
RA Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., Koetter P., Louis E.J.,
RA Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S.,
RA Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D.,
RA Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M.,
RA Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P.,
RA Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M.,
RA Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K.,
RA Zollner A., Hani J., Hoheisel J.D.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
RL Nature 387:87-90(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204511 / S288c / AB972;
RX PubMed=12844361; DOI=10.1186/gb-2003-4-7-r45;
RA Brachat S., Dietrich F.S., Voegeli S., Zhang Z., Stuart L., Lerch A.,
RA Gates K., Gaffney T.D., Philippsen P.;
RT "Reinvestigation of the Saccharomyces cerevisiae genome annotation by
RT comparison to the genome of a related fungus: Ashbya gossypii.";
RL Genome Biol. 4:R45.1-R45.13(2003).
RN [5]
RP INDUCTION.
RX PubMed=10657304; DOI=10.1126/science.287.5454.873;
RA Roberts C.J., Nelson B., Marton M.J., Stoughton R., Meyer M.R.,
RA Bennett H.A., He Y.D., Dai H., Walker W.L., Hughes T.R., Tyers M.,
RA Boone C., Friend S.H.;
RT "Signaling and circuitry of multiple MAPK pathways revealed by a matrix of
RT global gene expression profiles.";
RL Science 287:873-880(2000).
RN [6]
RP INDUCTION.
RX PubMed=12370439; DOI=10.1073/pnas.202495299;
RA Williams R.M., Primig M., Washburn B.K., Winzeler E.A., Bellis M.,
RA Sarrauste de Menthiere C., Davis R.W., Easton Esposito R.;
RT "The Ume6 regulon coordinates metabolic and meiotic gene expression in
RT yeast.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:13431-13436(2002).
RN [7]
RP FUNCTION.
RX PubMed=16464826; DOI=10.1093/nar/gkj493;
RA Titz B., Thomas S., Rajagopala S.V., Chiba T., Ito T., Uetz P.;
RT "Transcriptional activators in yeast.";
RL Nucleic Acids Res. 34:955-967(2006).
RN [8]
RP FUNCTION.
RX PubMed=22194413; DOI=10.1126/science.1215110;
RA Brar G.A., Yassour M., Friedman N., Regev A., Ingolia N.T., Weissman J.S.;
RT "High-resolution view of the yeast meiotic program revealed by ribosome
RT profiling.";
RL Science 335:552-557(2012).
CC -!- FUNCTION: Probable transcriptional activator involved in meiotic
CC prophase and synaptonemal complex (SC) assembly.
CC {ECO:0000269|PubMed:16464826, ECO:0000269|PubMed:22194413}.
CC -!- INTERACTION:
CC Q06201; Q04110: ECM11; NbExp=4; IntAct=EBI-3786338, EBI-37150;
CC -!- INDUCTION: Expression is induced in response to alpha factor and
CC regulated by the UME6 transcription factor.
CC {ECO:0000269|PubMed:10657304, ECO:0000269|PubMed:12370439}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB67531.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAS56556.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; U22382; AAB67531.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AY558230; AAS56556.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BK006945; DAA09745.1; -; Genomic_DNA.
DR PIR; S55967; S55967.
DR RefSeq; NP_013550.4; NM_001182333.3.
DR AlphaFoldDB; Q06201; -.
DR SMR; Q06201; -.
DR BioGRID; 31703; 48.
DR ComplexPortal; CPX-1387; Synaptonemal complex.
DR ComplexPortal; CPX-1407; ECM11-GMC2 synaptonemal assembly activation factor complex.
DR IntAct; Q06201; 1.
DR STRING; 4932.YLR445W; -.
DR PaxDb; Q06201; -.
DR PRIDE; Q06201; -.
DR EnsemblFungi; YLR445W_mRNA; YLR445W; YLR445W.
DR GeneID; 851166; -.
DR KEGG; sce:YLR445W; -.
DR SGD; S000004437; GMC2.
DR VEuPathDB; FungiDB:YLR445W; -.
DR eggNOG; ENOG502S5T2; Eukaryota.
DR HOGENOM; CLU_122928_0_0_1; -.
DR InParanoid; Q06201; -.
DR OMA; DTTEVPR; -.
DR BioCyc; YEAST:G3O-32500-MON; -.
DR PRO; PR:Q06201; -.
DR Proteomes; UP000002311; Chromosome XII.
DR RNAct; Q06201; protein.
DR GO; GO:0000794; C:condensed nuclear chromosome; IDA:ComplexPortal.
DR GO; GO:0000795; C:synaptonemal complex; IDA:SGD.
DR GO; GO:0007129; P:homologous chromosome pairing at meiosis; IC:ComplexPortal.
DR GO; GO:0035825; P:homologous recombination; IC:ComplexPortal.
DR GO; GO:0051321; P:meiotic cell cycle; IMP:SGD.
DR GO; GO:0016925; P:protein sumoylation; IMP:SGD.
DR GO; GO:0007131; P:reciprocal meiotic recombination; IMP:SGD.
DR GO; GO:0007130; P:synaptonemal complex assembly; IMP:ComplexPortal.
DR GO; GO:0070193; P:synaptonemal complex organization; IMP:SGD.
PE 1: Evidence at protein level;
KW Activator; Meiosis; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..188
FT /note="Grand meiotic recombination cluster protein 2"
FT /id="PRO_0000247355"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 188 AA; 22365 MW; ADDEDD26FAFAF9D7 CRC64;
MSDTTEVPRQ SSENDQDNNL ERTNSLKSPD VTNNIPSLFK LAAEWQINNP QETFQNHILE
NDVLKKINEI THLIRESYKD LSSQDGMMSK QQQEKMDWDL FCTVPVNIIE QYTKDMDEIY
EKMERLAKQQ RLWCESAFQI DVERCGDSIL NAETWMKKKE RHLEYKNIEM ERSANEIKET
IQRLTDDR
