GMFB_BOVIN
ID GMFB_BOVIN Reviewed; 142 AA.
AC P60984; A7E313; P17774;
DT 26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Glia maturation factor beta;
DE Short=GMF-beta;
GN Name=GMFB;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Hypothalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP PROTEIN SEQUENCE OF 2-142, AND ACETYLATION AT SER-2.
RX PubMed=2196564; DOI=10.1073/pnas.87.14.5233;
RA Lim R., Zaheer A., Lane W.S.;
RT "Complete amino acid sequence of bovine glia maturation factor beta.";
RL Proc. Natl. Acad. Sci. U.S.A. 87:5233-5237(1990).
CC -!- FUNCTION: This protein causes differentiation of brain cells,
CC stimulation of neural regeneration, and inhibition of proliferation of
CC tumor cells.
CC -!- PTM: Phosphorylated; stimulated by phorbol ester. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the actin-binding proteins ADF family. GMF
CC subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC151658; AAI51659.1; -; mRNA.
DR PIR; A33102; JDBOB.
DR RefSeq; NP_001094707.1; NM_001101237.1.
DR AlphaFoldDB; P60984; -.
DR SMR; P60984; -.
DR STRING; 9913.ENSBTAP00000041259; -.
DR iPTMnet; P60984; -.
DR PaxDb; P60984; -.
DR PeptideAtlas; P60984; -.
DR PRIDE; P60984; -.
DR Ensembl; ENSBTAT00000072079; ENSBTAP00000064206; ENSBTAG00000054095.
DR GeneID; 615255; -.
DR KEGG; bta:615255; -.
DR CTD; 2764; -.
DR VEuPathDB; HostDB:ENSBTAG00000054095; -.
DR VGNC; VGNC:29434; GMFB.
DR eggNOG; KOG1736; Eukaryota.
DR GeneTree; ENSGT00390000008920; -.
DR HOGENOM; CLU_087056_1_0_1; -.
DR InParanoid; P60984; -.
DR OMA; PFIVYSY; -.
DR OrthoDB; 1477747at2759; -.
DR TreeFam; TF315147; -.
DR Proteomes; UP000009136; Chromosome 10.
DR Bgee; ENSBTAG00000054095; Expressed in occipital lobe and 105 other tissues.
DR ExpressionAtlas; P60984; baseline.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0071933; F:Arp2/3 complex binding; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0034316; P:negative regulation of Arp2/3 complex-mediated actin nucleation; IEA:InterPro.
DR CDD; cd11283; ADF_GMF-beta_like; 1.
DR Gene3D; 3.40.20.10; -; 1.
DR InterPro; IPR002108; ADF-H.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR011171; GMF.
DR PANTHER; PTHR11249; PTHR11249; 1.
DR Pfam; PF00241; Cofilin_ADF; 1.
DR PIRSF; PIRSF001788; GMF-beta; 1.
DR SMART; SM00102; ADF; 1.
DR PROSITE; PS51263; ADF_H; 1.
PE 1: Evidence at protein level;
KW Acetylation; Direct protein sequencing; Growth factor; Phosphoprotein;
KW Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:2196564"
FT CHAIN 2..142
FT /note="Glia maturation factor beta"
FT /id="PRO_0000214942"
FT DOMAIN 4..139
FT /note="ADF-H"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00599"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000269|PubMed:2196564"
SQ SEQUENCE 142 AA; 16713 MW; CF2D4A8CB1F37B1F CRC64;
MSESLVVCDV AEDLVEKLRK FRFRKETNNA AIIMKIDKDK RLVVLDEELE GISPDELKDE
LPERQPRFIV YSYKYQHDDG RVSYPLCFIF SSPVGCKPEQ QMMYAGSKNK LVQTAELTKV
FEIRNTEDLT EEWLREKLGF FH
