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GMFB_HUMAN
ID   GMFB_HUMAN              Reviewed;         142 AA.
AC   P60983; B2R499; P17774; Q9BS35;
DT   26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 149.
DE   RecName: Full=Glia maturation factor beta;
DE            Short=GMF-beta;
GN   Name=GMFB;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1712830; DOI=10.1111/j.1471-4159.1991.tb03777.x;
RA   Kaplan R., Zaheer A., Jaye M., Lim R.;
RT   "Molecular cloning and expression of biologically active human glia
RT   maturation factor-beta.";
RL   J. Neurochem. 57:483-490(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RA   Saito T., Tanaka N., Toyomasu T.;
RL   Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA   Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA   Phelan M., Farmer A.;
RT   "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL   Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P.,
RA   Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y.,
RA   LaBaer J.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Amygdala;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Urinary bladder;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [8]
RP   PHOSPHORYLATION.
RX   PubMed=7598724; DOI=10.1006/bbrc.1995.1901;
RA   Lim R., Zaheer A.;
RT   "Phorbol ester stimulates rapid intracellular phosphorylation of glia
RT   maturation factor.";
RL   Biochem. Biophys. Res. Commun. 211:928-934(1995).
RN   [9]
RP   ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, CLEAVAGE OF INITIATOR
RP   METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP   [LARGE SCALE ANALYSIS].
RX   PubMed=19413330; DOI=10.1021/ac9004309;
RA   Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT   "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT   refined SCX-based approach.";
RL   Anal. Chem. 81:4493-4501(2009).
RN   [10]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [11]
RP   ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, CLEAVAGE OF INITIATOR
RP   METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP   [LARGE SCALE ANALYSIS].
RX   PubMed=22223895; DOI=10.1074/mcp.m111.015131;
RA   Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T.,
RA   Giglione C.;
RT   "Comparative large-scale characterisation of plant vs. mammal proteins
RT   reveals similar and idiosyncratic N-alpha acetylation features.";
RL   Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012).
RN   [12]
RP   ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, CLEAVAGE OF INITIATOR
RP   METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP   [LARGE SCALE ANALYSIS].
RX   PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA   Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA   Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA   Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT   "N-terminal acetylome analyses and functional insights of the N-terminal
RT   acetyltransferase NatB.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN   [13]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver;
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA   Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT   phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
CC   -!- FUNCTION: This protein causes differentiation of brain cells,
CC       stimulation of neural regeneration, and inhibition of proliferation of
CC       tumor cells.
CC   -!- PTM: Phosphorylated; stimulated by phorbol ester.
CC       {ECO:0000269|PubMed:7598724}.
CC   -!- SIMILARITY: Belongs to the actin-binding proteins ADF family. GMF
CC       subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH05359.1; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=AAP35430.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; M86492; AAA58614.1; -; mRNA.
DR   EMBL; AB001106; BAA19232.1; -; mRNA.
DR   EMBL; BT006784; AAP35430.1; ALT_FRAME; mRNA.
DR   EMBL; CR542113; CAG46910.1; -; mRNA.
DR   EMBL; AK311753; BAG34696.1; -; mRNA.
DR   EMBL; CH471061; EAW80638.1; -; Genomic_DNA.
DR   EMBL; BC005359; AAH05359.1; ALT_FRAME; mRNA.
DR   CCDS; CCDS9718.1; -.
DR   PIR; PT0410; PT0410.
DR   RefSeq; NP_004115.1; NM_004124.2.
DR   AlphaFoldDB; P60983; -.
DR   SMR; P60983; -.
DR   BioGRID; 109026; 20.
DR   IntAct; P60983; 1.
DR   STRING; 9606.ENSP00000350757; -.
DR   GlyGen; P60983; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; P60983; -.
DR   PhosphoSitePlus; P60983; -.
DR   BioMuta; GMFB; -.
DR   DMDM; 46577593; -.
DR   OGP; P17774; -.
DR   EPD; P60983; -.
DR   jPOST; P60983; -.
DR   MassIVE; P60983; -.
DR   MaxQB; P60983; -.
DR   PaxDb; P60983; -.
DR   PeptideAtlas; P60983; -.
DR   PRIDE; P60983; -.
DR   ProteomicsDB; 57242; -.
DR   TopDownProteomics; P60983; -.
DR   Antibodypedia; 23938; 250 antibodies from 30 providers.
DR   DNASU; 2764; -.
DR   Ensembl; ENST00000358056.8; ENSP00000350757.3; ENSG00000197045.13.
DR   Ensembl; ENST00000616146.4; ENSP00000479543.1; ENSG00000197045.13.
DR   GeneID; 2764; -.
DR   KEGG; hsa:2764; -.
DR   MANE-Select; ENST00000358056.8; ENSP00000350757.3; NM_004124.3; NP_004115.1.
DR   UCSC; uc021rtf.2; human.
DR   CTD; 2764; -.
DR   DisGeNET; 2764; -.
DR   GeneCards; GMFB; -.
DR   HGNC; HGNC:4373; GMFB.
DR   HPA; ENSG00000197045; Tissue enhanced (brain).
DR   MIM; 601713; gene.
DR   neXtProt; NX_P60983; -.
DR   OpenTargets; ENSG00000197045; -.
DR   PharmGKB; PA28758; -.
DR   VEuPathDB; HostDB:ENSG00000197045; -.
DR   eggNOG; KOG1736; Eukaryota.
DR   GeneTree; ENSGT00390000008920; -.
DR   HOGENOM; CLU_087056_1_0_1; -.
DR   InParanoid; P60983; -.
DR   OMA; PFIVYSY; -.
DR   OrthoDB; 1477747at2759; -.
DR   PhylomeDB; P60983; -.
DR   TreeFam; TF315147; -.
DR   PathwayCommons; P60983; -.
DR   SignaLink; P60983; -.
DR   SIGNOR; P60983; -.
DR   BioGRID-ORCS; 2764; 8 hits in 1064 CRISPR screens.
DR   ChiTaRS; GMFB; human.
DR   GenomeRNAi; 2764; -.
DR   Pharos; P60983; Tbio.
DR   PRO; PR:P60983; -.
DR   Proteomes; UP000005640; Chromosome 14.
DR   RNAct; P60983; protein.
DR   Bgee; ENSG00000197045; Expressed in dorsal motor nucleus of vagus nerve and 210 other tissues.
DR   ExpressionAtlas; P60983; baseline and differential.
DR   Genevisible; P60983; HS.
DR   GO; GO:0003779; F:actin binding; IEA:InterPro.
DR   GO; GO:0071933; F:Arp2/3 complex binding; IBA:GO_Central.
DR   GO; GO:0008047; F:enzyme activator activity; TAS:ProtInc.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004860; F:protein kinase inhibitor activity; TAS:ProtInc.
DR   GO; GO:0071846; P:actin filament debranching; IBA:GO_Central.
DR   GO; GO:0034316; P:negative regulation of Arp2/3 complex-mediated actin nucleation; IBA:GO_Central.
DR   GO; GO:0007399; P:nervous system development; TAS:ProtInc.
DR   GO; GO:0006468; P:protein phosphorylation; TAS:ProtInc.
DR   CDD; cd11283; ADF_GMF-beta_like; 1.
DR   Gene3D; 3.40.20.10; -; 1.
DR   InterPro; IPR002108; ADF-H.
DR   InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR   InterPro; IPR011171; GMF.
DR   PANTHER; PTHR11249; PTHR11249; 1.
DR   Pfam; PF00241; Cofilin_ADF; 1.
DR   PIRSF; PIRSF001788; GMF-beta; 1.
DR   SMART; SM00102; ADF; 1.
DR   PROSITE; PS51263; ADF_H; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Growth factor; Phosphoprotein; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0007744|PubMed:19413330,
FT                   ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378"
FT   CHAIN           2..142
FT                   /note="Glia maturation factor beta"
FT                   /id="PRO_0000214943"
FT   DOMAIN          4..139
FT                   /note="ADF-H"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00599"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0007744|PubMed:19413330,
FT                   ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378"
SQ   SEQUENCE   142 AA;  16713 MW;  CF2D4A8CB1F37B1F CRC64;
     MSESLVVCDV AEDLVEKLRK FRFRKETNNA AIIMKIDKDK RLVVLDEELE GISPDELKDE
     LPERQPRFIV YSYKYQHDDG RVSYPLCFIF SSPVGCKPEQ QMMYAGSKNK LVQTAELTKV
     FEIRNTEDLT EEWLREKLGF FH
 
 
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