ID   AMP1_PITHY              Reviewed;          12 AA.
AC   P84524;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   02-DEC-2020, entry version 22.
DE   RecName: Full=Antimicrobial peptide 1 {ECO:0000303|Ref.1};
OS   Pithecopus hypochondrialis (Orange-legged leaf frog) (Phyllomedusa
OS   hypochondrialis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC   Pithecopus.
OX   NCBI_TaxID=317381;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RA   Thompson A.H.;
RT   "Antimicrobial peptides derived from the venom of the South American tree
RT   frog, Phyllomedusa hypochondrialis.";
RL   Submitted (APR-2005) to UniProtKB.
CC   -!- FUNCTION: Has antimicrobial activity against the Gram-positive
CC       bacterium M.luteus. {ECO:0000269|Ref.1}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC   -!- MASS SPECTROMETRY: Mass=1335.87; Mass_error=0.01; Method=Electrospray;
CC       Evidence={ECO:0000269|Ref.1};
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amphibian defense peptide; Antibiotic; Antimicrobial;
KW   Direct protein sequencing; Secreted.
FT   PEPTIDE         1..12
FT                   /note="Antimicrobial peptide 1"
FT                   /evidence="ECO:0000269|Ref.1"
FT                   /id="PRO_0000043870"
FT   UNSURE          12
FT                   /note="L or I"
FT                   /evidence="ECO:0000303|Ref.1"
SQ   SEQUENCE   12 AA;  1337 MW;  D96D84E5C812C042 CRC64;
     LRPAVIVRTK AL