ID   GMFB_PONAB              Reviewed;         142 AA.
AC   Q5R6P6;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Glia maturation factor beta;
DE            Short=GMF-beta;
GN   Name=GMFB;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein causes differentiation of brain cells,
CC       stimulation of neural regeneration, and inhibition of proliferation of
CC       tumor cells. {ECO:0000250}.
CC   -!- PTM: Phosphorylated; stimulated by phorbol ester. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the actin-binding proteins ADF family. GMF
CC       subfamily. {ECO:0000305}.
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DR   EMBL; CR860440; CAH92564.1; -; mRNA.
DR   RefSeq; NP_001126503.1; NM_001133031.1.
DR   AlphaFoldDB; Q5R6P6; -.
DR   SMR; Q5R6P6; -.
DR   STRING; 9601.ENSPPYP00000006624; -.
DR   PRIDE; Q5R6P6; -.
DR   Ensembl; ENSPPYT00000006887; ENSPPYP00000006624; ENSPPYG00000005830.
DR   GeneID; 100173491; -.
DR   KEGG; pon:100173491; -.
DR   CTD; 2764; -.
DR   eggNOG; KOG1736; Eukaryota.
DR   GeneTree; ENSGT00390000008920; -.
DR   HOGENOM; CLU_087056_1_0_1; -.
DR   InParanoid; Q5R6P6; -.
DR   OrthoDB; 1477747at2759; -.
DR   Proteomes; UP000001595; Chromosome 14.
DR   GO; GO:0003779; F:actin binding; IEA:InterPro.
DR   GO; GO:0071933; F:Arp2/3 complex binding; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0034316; P:negative regulation of Arp2/3 complex-mediated actin nucleation; IEA:InterPro.
DR   CDD; cd11283; ADF_GMF-beta_like; 1.
DR   Gene3D; 3.40.20.10; -; 1.
DR   InterPro; IPR002108; ADF-H.
DR   InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR   InterPro; IPR011171; GMF.
DR   PANTHER; PTHR11249; PTHR11249; 1.
DR   Pfam; PF00241; Cofilin_ADF; 1.
DR   PIRSF; PIRSF001788; GMF-beta; 1.
DR   SMART; SM00102; ADF; 1.
DR   PROSITE; PS51263; ADF_H; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Growth factor; Phosphoprotein; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:P60984"
FT   CHAIN           2..142
FT                   /note="Glia maturation factor beta"
FT                   /id="PRO_0000214945"
FT   DOMAIN          4..139
FT                   /note="ADF-H"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00599"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250|UniProtKB:P60984"
SQ   SEQUENCE   142 AA;  16713 MW;  CF2D4A8CB1F37B1F CRC64;
     MSESLVVCDV AEDLVEKLRK FRFRKETNNA AIIMKIDKDK RLVVLDEELE GISPDELKDE
     LPERQPRFIV YSYKYQHDDG RVSYPLCFIF SSPVGCKPEQ QMMYAGSKNK LVQTAELTKV
     FEIRNTEDLT EEWLREKLGF FH