ID   GMFB_RAT                Reviewed;         142 AA.
AC   Q63228;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Glia maturation factor beta;
DE            Short=GMF-beta;
GN   Name=Gmfb;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8436977; DOI=10.1111/j.1471-4159.1993.tb03237.x;
RA   Zaheer A., Fink B.D., Lim R.;
RT   "Expression of glia maturation factor beta mRNA and protein in rat organs
RT   and cells.";
RL   J. Neurochem. 60:914-920(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   PROTEIN SEQUENCE OF 42-64, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=Sprague-Dawley; TISSUE=Hippocampus;
RA   Lubec G., Diao W.;
RL   Submitted (APR-2007) to UniProtKB.
RN   [4]
RP   ACETYLATION AT SER-2, AND IDENTIFICATION BY MASS SPECTROMETRY.
RA   Lubec G., Chen W.-Q.;
RL   Submitted (FEB-2007) to UniProtKB.
CC   -!- FUNCTION: This protein causes differentiation of brain cells,
CC       stimulation of neural regeneration, and inhibition of proliferation of
CC       tumor cells. {ECO:0000250}.
CC   -!- PTM: Phosphorylated; stimulated by phorbol ester. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the actin-binding proteins ADF family. GMF
CC       subfamily. {ECO:0000305}.
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DR   EMBL; Z11558; CAA77650.1; -; mRNA.
DR   EMBL; BC081778; AAH81778.1; -; mRNA.
DR   PIR; S22149; S22149.
DR   RefSeq; NP_112294.1; NM_031032.2.
DR   AlphaFoldDB; Q63228; -.
DR   SMR; Q63228; -.
DR   BioGRID; 249561; 3.
DR   IntAct; Q63228; 1.
DR   MINT; Q63228; -.
DR   STRING; 10116.ENSRNOP00000067695; -.
DR   iPTMnet; Q63228; -.
DR   PhosphoSitePlus; Q63228; -.
DR   SwissPalm; Q63228; -.
DR   jPOST; Q63228; -.
DR   PaxDb; Q63228; -.
DR   PRIDE; Q63228; -.
DR   Ensembl; ENSRNOT00000101993; ENSRNOP00000089942; ENSRNOG00000064480.
DR   GeneID; 81661; -.
DR   KEGG; rno:81661; -.
DR   UCSC; RGD:70910; rat.
DR   CTD; 2764; -.
DR   RGD; 70910; Gmfb.
DR   eggNOG; KOG1736; Eukaryota.
DR   GeneTree; ENSGT00390000008920; -.
DR   InParanoid; Q63228; -.
DR   OrthoDB; 1477747at2759; -.
DR   PRO; PR:Q63228; -.
DR   Proteomes; UP000002494; Chromosome 15.
DR   GO; GO:0003779; F:actin binding; IEA:InterPro.
DR   GO; GO:0071933; F:Arp2/3 complex binding; IBA:GO_Central.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0071846; P:actin filament debranching; IBA:GO_Central.
DR   GO; GO:0007612; P:learning; ISO:RGD.
DR   GO; GO:0007626; P:locomotory behavior; ISO:RGD.
DR   GO; GO:0034316; P:negative regulation of Arp2/3 complex-mediated actin nucleation; IBA:GO_Central.
DR   CDD; cd11283; ADF_GMF-beta_like; 1.
DR   Gene3D; 3.40.20.10; -; 1.
DR   InterPro; IPR002108; ADF-H.
DR   InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR   InterPro; IPR011171; GMF.
DR   PANTHER; PTHR11249; PTHR11249; 1.
DR   Pfam; PF00241; Cofilin_ADF; 1.
DR   PIRSF; PIRSF001788; GMF-beta; 1.
DR   SMART; SM00102; ADF; 1.
DR   PROSITE; PS51263; ADF_H; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Direct protein sequencing; Growth factor; Phosphoprotein;
KW   Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|Ref.4"
FT   CHAIN           2..142
FT                   /note="Glia maturation factor beta"
FT                   /id="PRO_0000214946"
FT   DOMAIN          4..139
FT                   /note="ADF-H"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00599"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000269|Ref.4"
SQ   SEQUENCE   142 AA;  16736 MW;  A36B8D8D82B44F6C CRC64;
     MSESLVVCDV AEDLVEKLRK FRFRKETHNA AIIMKIDKDK RLVVLDEELE GVSPDELKDE
     LPERQPRFIV YSYKYQHDDG RVSYPLCFIF SSPLGCKPEQ QMMYAGSKNK LVQTAELTKV
     FEIRNTEDLT EEWLREKLGF FH