ID   GMFG_RAT                Reviewed;         142 AA.
AC   Q80T18;
DT   26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Glia maturation factor gamma;
DE            Short=GMF-gamma;
GN   Name=Gmfg;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Pulmonary artery;
RX   PubMed=10731725; DOI=10.1093/oxfordjournals.jbchem.a022635;
RA   Tsuiki H., Asai K., Yamamoto M., Fujita K., Inoue Y., Kawai Y., Tada T.,
RA   Moriyama A., Wada Y., Kato T.;
RT   "Cloning of a rat glia maturation factor-gamma (rGMFG) cDNA and expression
RT   of its mRNA and protein in rat organs.";
RL   J. Biochem. 127:517-523(2000).
CC   -!- TISSUE SPECIFICITY: Expressed in rat thymus, testis, and spleen. Is
CC       present predominantly in proliferative and differentiative organs.
CC   -!- SIMILARITY: Belongs to the actin-binding proteins ADF family. GMF
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AB007364; BAC76430.1; -; mRNA.
DR   RefSeq; NP_851605.1; NM_181091.2.
DR   AlphaFoldDB; Q80T18; -.
DR   SMR; Q80T18; -.
DR   STRING; 10116.ENSRNOP00000026891; -.
DR   iPTMnet; Q80T18; -.
DR   PhosphoSitePlus; Q80T18; -.
DR   PaxDb; Q80T18; -.
DR   PRIDE; Q80T18; -.
DR   GeneID; 113940; -.
DR   KEGG; rno:113940; -.
DR   CTD; 9535; -.
DR   RGD; 620506; Gmfg.
DR   eggNOG; KOG1736; Eukaryota.
DR   InParanoid; Q80T18; -.
DR   PhylomeDB; Q80T18; -.
DR   Reactome; R-RNO-6798695; Neutrophil degranulation.
DR   PRO; PR:Q80T18; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0003779; F:actin binding; IEA:InterPro.
DR   GO; GO:0071933; F:Arp2/3 complex binding; IBA:GO_Central.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0019207; F:kinase regulator activity; NAS:RGD.
DR   GO; GO:0071846; P:actin filament debranching; ISO:RGD.
DR   GO; GO:0034316; P:negative regulation of Arp2/3 complex-mediated actin nucleation; ISO:RGD.
DR   GO; GO:2000249; P:regulation of actin cytoskeleton reorganization; IEA:InterPro.
DR   CDD; cd11283; ADF_GMF-beta_like; 1.
DR   Gene3D; 3.40.20.10; -; 1.
DR   InterPro; IPR002108; ADF-H.
DR   InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR   InterPro; IPR011171; GMF.
DR   InterPro; IPR030076; GMFG.
DR   PANTHER; PTHR11249; PTHR11249; 1.
DR   PANTHER; PTHR11249:SF4; PTHR11249:SF4; 1.
DR   Pfam; PF00241; Cofilin_ADF; 1.
DR   PIRSF; PIRSF001788; GMF-beta; 1.
DR   SMART; SM00102; ADF; 1.
DR   PROSITE; PS51263; ADF_H; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Growth factor; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:O60234"
FT   CHAIN           2..142
FT                   /note="Glia maturation factor gamma"
FT                   /id="PRO_0000214949"
FT   DOMAIN          4..139
FT                   /note="ADF-H"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00599"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250|UniProtKB:O60234"
SQ   SEQUENCE   142 AA;  16779 MW;  B5468FC5F2EFFA05 CRC64;
     MSDSLVVCDV DPELKETLRK FRFRKETNNA AIIMKVDKDR QMVVLEDEFQ NVSPEELKLE
     LPERQPRFVV YSYKYVHDDG RVSYPLCFIF SSPVGCKPEQ QMMYAGSKNR LVQIAELTKV
     FEIRTTDDLN ETWLKEKLAF FR