ID   AMP1_SCOMU              Reviewed;          21 AA.
AC   P0CH48;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2010, sequence version 1.
DT   25-MAY-2022, entry version 13.
DE   RecName: Full=Antimicrobial peptide scolopin-1 {ECO:0000303|PubMed:19716842};
OS   Scolopendra mutilans (Chinese red-headed centipede) (Scolopendra
OS   subspinipes mutilans).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC   Pleurostigmophora; Scolopendromorpha; Scolopendridae; Scolopendra.
OX   NCBI_TaxID=2836329;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, SYNTHESIS, MASS SPECTROMETRY, AND SUBCELLULAR
RP   LOCATION.
RC   TISSUE=Venom;
RX   PubMed=19716842; DOI=10.1016/j.toxicon.2009.07.040;
RA   Peng K., Kong Y., Zhai L., Wu X., Jia P., Liu J., Yu H.;
RT   "Two novel antimicrobial peptides from centipede venoms.";
RL   Toxicon 55:274-279(2010).
CC   -!- FUNCTION: Antimicrobial peptide against both Gram-positive, -negative
CC       and yeast. Also induces histamine release by mast cells and shows
CC       moderate hemolytic activities against both human and rabbit red cells.
CC       {ECO:0000269|PubMed:19716842}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19716842}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:19716842}.
CC   -!- MASS SPECTROMETRY: Mass=2594.94; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:19716842};
CC   -!- MISCELLANEOUS: Minimum inhibitory concentrations (MIC) are the
CC       following: E.coli standard strain (MIC=12.5 ug/ml), E.coli drug-
CC       resistant strain (MIC=15 ug/ml), S.aureus standard strain (MIC=1.2
CC       ug/ml), S.aureus drug-resistant strain (MIC=5.0 ug/ml), B.dysenteriae
CC       standard and drug-resistant strains (MIC=7.5 ug/ml) and C.albicans
CC       (MIC=15 ug/ml).
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DR   AlphaFoldDB; P0CH48; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Cytolysis; Direct protein sequencing; Fungicide;
KW   Hemolysis; Secreted.
FT   PEPTIDE         1..21
FT                   /note="Antimicrobial peptide scolopin-1"
FT                   /evidence="ECO:0000269|PubMed:19716842"
FT                   /id="PRO_0000398338"
SQ   SEQUENCE   21 AA;  2594 MW;  AD98396EFDCBA356 CRC64;
     FLPKMSTKLR VPYRRGTKDY H