3S15_HYDSC
ID 3S15_HYDSC Reviewed; 60 AA.
AC P62389; P01436; P25493;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 59.
DE RecName: Full=Toxin 5;
OS Hydrophis schistosus (Beaked sea snake) (Enhydrina schistosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Hydrophiidae; Hydrophis.
OX NCBI_TaxID=8682;
RN [1]
RP PROTEIN SEQUENCE, AND SUBCELLULAR LOCATION.
RC TISSUE=Venom;
RX PubMed=4676045; DOI=10.1021/bi00774a034;
RA Fryklund L., Eaker D., Karlsson E.;
RT "Amino acid sequences of the two principal neurotoxins of Enhydrina
RT schistosa venom.";
RL Biochemistry 11:4633-4640(1972).
CC -!- FUNCTION: Binds to muscle nicotinic acetylcholine receptor (nAChR) and
CC inhibit acetylcholine from binding to the receptor, thereby impairing
CC neuromuscular transmission. {ECO:0000250|UniProtKB:P60775}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:4676045}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-chain
CC subfamily. Type I alpha-neurotoxin sub-subfamily. {ECO:0000305}.
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DR PIR; B01705; N1EY15.
DR AlphaFoldDB; P62389; -.
DR SMR; P62389; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR CDD; cd00206; snake_toxin; 1.
DR Gene3D; 2.10.60.10; -; 1.
DR InterPro; IPR003571; Snake_3FTx.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR InterPro; IPR018354; Snake_toxin_con_site.
DR SUPFAM; SSF57302; SSF57302; 1.
DR PROSITE; PS00272; SNAKE_TOXIN; 1.
PE 1: Evidence at protein level;
KW Acetylcholine receptor inhibiting toxin; Direct protein sequencing;
KW Disulfide bond; Ion channel impairing toxin; Neurotoxin;
KW Postsynaptic neurotoxin; Secreted; Toxin.
FT CHAIN 1..60
FT /note="Toxin 5"
FT /evidence="ECO:0000269|PubMed:4676045"
FT /id="PRO_0000093580"
FT DISULFID 3..22
FT /evidence="ECO:0000250|UniProtKB:P0C1Z0"
FT DISULFID 17..39
FT /evidence="ECO:0000250|UniProtKB:P0C1Z0"
FT DISULFID 41..52
FT /evidence="ECO:0000250|UniProtKB:P0C1Z0"
FT DISULFID 53..58
FT /evidence="ECO:0000250|UniProtKB:P0C1Z0"
SQ SEQUENCE 60 AA; 6687 MW; C5C9081D1156E59A CRC64;
MTCCNQQSSQ PKTTTNCAES SCYKKTWSDH RGTRIERGCG CPQVKSGIKL ECCHTNECNN
