ID   AMP1_TAROF              Reviewed;          38 AA.
AC   B3EWQ1;
DT   03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 1.
DT   25-MAY-2022, entry version 7.
DE   RecName: Full=Antimicrobial peptide 1 {ECO:0000303|PubMed:22640720};
DE            Short=ToAMP1 {ECO:0000303|PubMed:22640720};
OS   Taraxacum officinale (Common dandelion) (Leontodon taraxacum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae;
OC   Crepidinae; Taraxacum.
OX   NCBI_TaxID=50225;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, TISSUE SPECIFICITY, DISULFIDE BOND, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Sepal {ECO:0000269|PubMed:22640720};
RX   PubMed=22640720; DOI=10.1016/j.peptides.2012.05.009;
RA   Astafieva A.A., Rogozhin E.A., Odintsova T.I., Khadeeva N.V., Grishin E.V.,
RA   Egorov T.S.A.;
RT   "Discovery of novel antimicrobial peptides with unusual cysteine motifs in
RT   dandelion Taraxacum officinale Wigg. flowers.";
RL   Peptides 36:266-271(2012).
CC   -!- FUNCTION: Antimicrobial peptide. Active against fungal species
CC       B.cinerea (IC(50)=5.8 uM) and A.niger (IC(50)=5.6 uM) but not against
CC       F.oxysporum, F.graminearum, B.sorokinina and P.debaryanum at
CC       concentrations below 10 uM. Active against bacterial species
CC       P.syringae, B.subtilis and X.campestris. {ECO:0000269|PubMed:22640720}.
CC   -!- TISSUE SPECIFICITY: Expressed in flowers but not in leaves, seeds or
CC       roots (at protein level). {ECO:0000269|PubMed:22640720}.
CC   -!- PTM: Disulfide bonds. {ECO:0000269|PubMed:22640720}.
CC   -!- MASS SPECTROMETRY: Mass=4341.1; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:22640720};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; B3EWQ1; -.
DR   GO; GO:0050832; P:defense response to fungus; IDA:UniProtKB.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Direct protein sequencing; Disulfide bond;
KW   Fungicide.
FT   PEPTIDE         1..38
FT                   /note="Antimicrobial peptide 1"
FT                   /evidence="ECO:0000269|PubMed:22640720"
FT                   /id="PRO_0000419497"
SQ   SEQUENCE   38 AA;  4349 MW;  FE20EC7D739FDF33 CRC64;
     VAKCTEESGG KYFVFCCYKP TRICYMNEQK CESTCIGK