AMP2_SCOMU
ID AMP2_SCOMU Reviewed; 25 AA.
AC P0CH49;
DT 05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 1.
DT 25-MAY-2022, entry version 14.
DE RecName: Full=Antimicrobial peptide scolopin-2 {ECO:0000303|PubMed:19716842};
OS Scolopendra mutilans (Chinese red-headed centipede) (Scolopendra
OS subspinipes mutilans).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC Pleurostigmophora; Scolopendromorpha; Scolopendridae; Scolopendra.
OX NCBI_TaxID=2836329;
RN [1]
RP PROTEIN SEQUENCE, FUNCTION, SYNTHESIS, MASS SPECTROMETRY, AND SUBCELLULAR
RP LOCATION.
RC TISSUE=Venom;
RX PubMed=19716842; DOI=10.1016/j.toxicon.2009.07.040;
RA Peng K., Kong Y., Zhai L., Wu X., Jia P., Liu J., Yu H.;
RT "Two novel antimicrobial peptides from centipede venoms.";
RL Toxicon 55:274-279(2010).
CC -!- FUNCTION: Antimicrobial peptide against both Gram-positive, -negative
CC and yeast. Also induces histamine release by mast cells and shows
CC moderate hemolytic activities against both human and rabbit red cells.
CC {ECO:0000269|PubMed:19716842}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19716842}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC {ECO:0000305|PubMed:19716842}.
CC -!- MASS SPECTROMETRY: Mass=3018.60; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:19716842};
CC -!- MISCELLANEOUS: Minimum inhibitory concentrations (MIC) are the
CC following: E.coli standard and drug-resistant strains (MIC=5.0 ug/ml),
CC S.aureus standard strain (MIC=0.5 ug/ml), S.aureus drug-resistant
CC strain (MIC=1.0 ug/ml), B.dysenteriae standard strain (MIC=2.5 ug/ml),
CC B.dysenteriae drug-resistant strain (MIC=5.0 ug/ml) and C.albicans
CC (MIC=7.5 ug/ml).
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DR AlphaFoldDB; P0CH49; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Antibiotic; Antimicrobial; Cytolysis; Direct protein sequencing; Fungicide;
KW Hemolysis; Secreted.
FT PEPTIDE 1..25
FT /note="Antimicrobial peptide scolopin-2"
FT /evidence="ECO:0000269|PubMed:19716842"
FT /id="PRO_0000398339"
SQ SEQUENCE 25 AA; 3017 MW; 5AA1EEBFBE60676B CRC64;
GILKKFMLHR GTKVYKMRTL SKRSH