ID   GMI1_ARATH              Reviewed;        1598 AA.
AC   F4KFS5; Q9FNF4;
DT   25-APR-2018, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Structural maintenance of chromosomes flexible hinge domain-containing protein GMI1 {ECO:0000305};
DE            Short=SMC hinge domain-containing protein GMI1 {ECO:0000305};
DE   AltName: Full=Protein GAMMA-IRRADIATION AND MITOMYCIN C INDUCED 1 {ECO:0000303|PubMed:21481027};
GN   Name=GMI1 {ECO:0000303|PubMed:21481027};
GN   OrderedLocusNames=At5g24280 {ECO:0000312|Araport:AT5G24280};
GN   ORFNames=MOP9.10 {ECO:0000312|EMBL:BAB10394.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=9405937; DOI=10.1093/dnares/4.4.291;
RA   Kotani H., Nakamura Y., Sato S., Kaneko T., Asamizu E., Miyajima N.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. II. Sequence
RT   features of the regions of 1,044,062 bp covered by thirteen physically
RT   assigned P1 clones.";
RL   DNA Res. 4:291-300(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   FUNCTION, TISSUE SPECIFICITY, INDUCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=21481027; DOI=10.1111/j.1365-313x.2011.04604.x;
RA   Boehmdorfer G., Schleiffer A., Brunmeir R., Ferscha S., Nizhynska V.,
RA   Kozak J., Angelis K.J., Kreil D.P., Schweizer D.;
RT   "GMI1, a structural-maintenance-of-chromosomes-hinge domain-containing
RT   protein, is involved in somatic homologous recombination in Arabidopsis.";
RL   Plant J. 67:420-433(2011).
CC   -!- FUNCTION: Contributes to DNA double-strand break (DSB) repair via
CC       somatic homologous recombination. Functions downstream of ATM.
CC       {ECO:0000269|PubMed:21481027}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in closed buds and open flowers.
CC       Expressed at low levels in roots, stems, cauline leaves and siliques.
CC       Expressed in the region of the shoot and floral meristems.
CC       {ECO:0000269|PubMed:21481027}.
CC   -!- INDUCTION: Induced by mitomycin C, bleocin and gamma-irradiation.
CC       {ECO:0000269|PubMed:21481027}.
CC   -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC       conditions, but mutant seedlings exhibit drastic reduction of somatic
CC       homologous recombination rate after treatment with bleocin or mitomycin
CC       C. {ECO:0000269|PubMed:21481027}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB10394.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AB006701; BAB10394.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002688; AED93279.1; -; Genomic_DNA.
DR   RefSeq; NP_197816.3; NM_122334.3.
DR   AlphaFoldDB; F4KFS5; -.
DR   SMR; F4KFS5; -.
DR   STRING; 3702.AT5G24280.1; -.
DR   PaxDb; F4KFS5; -.
DR   PRIDE; F4KFS5; -.
DR   ProteomicsDB; 248435; -.
DR   EnsemblPlants; AT5G24280.1; AT5G24280.1; AT5G24280.
DR   GeneID; 832495; -.
DR   Gramene; AT5G24280.1; AT5G24280.1; AT5G24280.
DR   KEGG; ath:AT5G24280; -.
DR   Araport; AT5G24280; -.
DR   TAIR; locus:2169799; AT5G24280.
DR   eggNOG; ENOG502QQS5; Eukaryota.
DR   HOGENOM; CLU_003046_0_0_1; -.
DR   InParanoid; F4KFS5; -.
DR   OrthoDB; 1084030at2759; -.
DR   PRO; PR:F4KFS5; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; F4KFS5; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IMP:TAIR.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   SUPFAM; SSF55874; SSF55874; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; DNA damage; DNA repair; Nucleus; Reference proteome.
FT   CHAIN           1..1598
FT                   /note="Structural maintenance of chromosomes flexible hinge
FT                   domain-containing protein GMI1"
FT                   /id="PRO_0000443824"
FT   REGION          1191..1218
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1258..1301
FT                   /evidence="ECO:0000255"
FT   COILED          1565..1595
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1598 AA;  179125 MW;  90E9BC7FDE0C40BA CRC64;
     MSSRRSVKRS LVLDDDDDED IFYNFKVLLP NGTSVKLTLK NPEPEISMQS FVNLVKKEYD
     NARKDCLLMS KRMKVDWNSG GKFHLESNGG KMKGIVRFAA FKPDLCHIIR LDDGSGIAST
     MYENLWDLTP DTDLLKELPE NYSFETALAD LIDNSLQAVW PYREGARKLI SVDISGDHIT
     VFDTGRGMDS SEGNSIDKWG KIGASLHRSQ KTGAIGGNPP YLKPYFGMFG YGGPYASMFL
     GRCDFSFCLP ILICIVLLRL TLFSVRRTLV SSKTKESKKV FTLQFKKEAL IDNRSIVGKN
     WKTDGGMRDP SEEEMKLSPH GSFTKVEIFE SEFDISKIYQ LQCRLKDIYF PYIQFCLATI
     FLCDELSKTG RTERPVAFQV NGEDLAEIAG GEVAITNLHS KGQFFSFQIR FTLFGGKRKG
     TAQEANARLK FVYFPIVQGK ESIEKILQSL EEEGCKVSES FQTFGRVSLR RLGRLLPEVR
     WDSIPFMQRG NRASTLQKSC RRVKCFVDLD AGFSPTPSKT DLASQNPFSV ALRNFGSKST
     EKEKDDDVNI VIHREGKSVS YAHLEEKYQE WVLEMHNTHD EEAASGLDEA VLIVGSLDKK
     ALGILRDAVR VHKEVRRKEK TWKRGQNIKI LRGAYAGIHN NNVYATIDYF LIEGFEDEAG
     GDTRILCRPI DRPENEGCKL SIIDGISKLE VQSSLSLPIT IIDSGKCLPV DANEWNRKLD
     KQQEKAPSKI DLLDERDCRE LKIDGELPIG NSVRAGKAPP KQIVAVVRPA CFTSLTPSKK
     LDQKNIVKMD GEEMVMVVKL KSSDKNISSQ RLFPTSRKGI SGLYIFSLGS KFPNLFKKAG
     TYNFSFSIGN SIKCNKTVVV RPSSKAARWE LDDNLESLPC NVRVGSSLPP FRIACFDKYK
     NKIPFTSVPS LEVELEASPG FLIKIDKLET NLINDGLILK IENMLVETDE LDQIRPNYEA
     TLEIRAMDNP FSVSVPCKVN PGPLKRVAVN NPKALENLLP DSTVEDFILE LFDGYNNHVA
     EGTDVLIHID GYRIEDWMGI NRKVDSRGCI NLSGILKVTE GYGKSVSLSV MSGNEVIFCK
     ESQIDERQLR LVTELPDCCT AGTNLMNLIF QVTELDGSLD TSIHHDEKSG CFHTMSIESD
     SSSVESAIRY AFVHGSCKVS SLSLPENEGV FSCRVFHSRY PELQMSIKIQ VTSAPTSERE
     ESGYSTPHSK TTPPPESGIP SITNPWPTPC SQFGVLAIRS SSLALSSETS LMDMAQYTED
     LKEKINIDEE RRVELEERLK CLQAQREHAE QECSRLQASL EPLGAPFPEC LSTKESMMKQ
     IEEKHHDTAA SVFCCLYRKA PPPRSLFLSQ KGMFGVVALL GSVASTSLSR VLSEYLGKDT
     MLSLVCKSSQ FGPKSDEYRK FQSEAASLGR SITNRFLVIC LDATRPWRNG LVRNDPQKRL
     AMDNPYLPNG DPIPGFKGYA VNMIDLASEE LDIQSSSGYG LRETLFYGVF RELQVYETAE
     HLEAALPHIN GGDAVSLDGV IARENGFIYS GCCTPEVHFP ITVTERQEKA LVQLEITRDK
     KRKTEEMMTE ENRSLRRLVK KLKKANEKYQ NFTAMADS