GMK1_ORYSJ
ID GMK1_ORYSJ Reviewed; 382 AA.
AC Q2QPW1; A0A0P0YAW3;
DT 03-SEP-2014, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2006, sequence version 2.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Guanylate kinase 1;
DE Short=OsGK1;
DE EC=2.7.4.8;
DE AltName: Full=GMP kinase 1;
GN Name=GK1; OrderedLocusNames=Os12g0515600, LOC_Os12g33100;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND SUBCELLULAR LOCATION.
RC STRAIN=cv. Taichung 65;
RX PubMed=17727616; DOI=10.1111/j.1365-313x.2007.03251.x;
RA Sugimoto H., Kusumi K., Noguchi K., Yano M., Yoshimura A., Iba K.;
RT "The rice nuclear gene, VIRESCENT 2, is essential for chloroplast
RT development and encodes a novel type of guanylate kinase targeted to
RT plastids and mitochondria.";
RL Plant J. 52:512-527(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16188032; DOI=10.1186/1741-7007-3-20;
RG The rice chromosomes 11 and 12 sequencing consortia;
RT "The sequence of rice chromosomes 11 and 12, rich in disease resistance
RT genes and recent gene duplications.";
RL BMC Biol. 3:20-20(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
CC -!- FUNCTION: Essential for recycling GMP and indirectly, cGMP.
CC {ECO:0000269|PubMed:17727616}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + GMP = ADP + GDP; Xref=Rhea:RHEA:20780,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58115, ChEBI:CHEBI:58189,
CC ChEBI:CHEBI:456216; EC=2.7.4.8;
CC -!- SUBUNIT: Monomer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17727616}. Nucleus
CC {ECO:0000269|PubMed:17727616}. Note=Predominantly cytoplasmic.
CC -!- MISCELLANEOUS: Plants silencing GK1 have no visible phenotype.
CC {ECO:0000305|PubMed:17727616}.
CC -!- SIMILARITY: Belongs to the guanylate kinase family. {ECO:0000305}.
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DR EMBL; AB267729; BAF46275.1; -; mRNA.
DR EMBL; DP000011; ABA98706.2; -; Genomic_DNA.
DR EMBL; AP008218; BAF29906.1; -; Genomic_DNA.
DR EMBL; AP014968; BAT17372.1; -; Genomic_DNA.
DR RefSeq; XP_015620685.1; XM_015765199.1.
DR AlphaFoldDB; Q2QPW1; -.
DR SMR; Q2QPW1; -.
DR STRING; 4530.OS12T0515600-01; -.
DR PaxDb; Q2QPW1; -.
DR PRIDE; Q2QPW1; -.
DR EnsemblPlants; Os12t0515600-01; Os12t0515600-01; Os12g0515600.
DR GeneID; 4352344; -.
DR Gramene; Os12t0515600-01; Os12t0515600-01; Os12g0515600.
DR KEGG; osa:4352344; -.
DR eggNOG; KOG0707; Eukaryota.
DR HOGENOM; CLU_037258_0_0_1; -.
DR InParanoid; Q2QPW1; -.
DR OMA; RIIDDAP; -.
DR OrthoDB; 1522834at2759; -.
DR BRENDA; 2.7.4.8; 8948.
DR Proteomes; UP000000763; Chromosome 12.
DR Proteomes; UP000059680; Chromosome 12.
DR Genevisible; Q2QPW1; OS.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004385; F:guanylate kinase activity; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00328; Guanylate_kinase; 1.
DR InterPro; IPR011043; Gal_Oxase/kelch_b-propeller.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR017665; Guanylate_kinase.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00625; Guanylate_kin; 1.
DR SMART; SM00072; GuKc; 1.
DR SUPFAM; SSF50965; SSF50965; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR03263; guanyl_kin; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Cytoplasm; Kinase; Nucleotide-binding; Nucleus;
KW Reference proteome; Transferase.
FT CHAIN 1..382
FT /note="Guanylate kinase 1"
FT /id="PRO_0000430128"
FT DOMAIN 128..310
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000250"
FT ACT_SITE 168
FT /evidence="ECO:0000250"
FT ACT_SITE 261
FT /evidence="ECO:0000250"
FT ACT_SITE 272
FT /evidence="ECO:0000250"
FT BINDING 135..142
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
FT BINDING 295
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
FT BINDING 296
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
SQ SEQUENCE 382 AA; 42014 MW; D08262E054B87CD3 CRC64;
MGEEAPEFRV ESVALESKDC LQNAIDIGDK TYVISRSDDP KSSITIKILD KLTQTWVVPT
VLGAPPNPTS SHSAVLVNNE KILIIEKGVP LNDSIWFLEV DTPFVKQQSK IKGTVVVAWS
KGVIGEGQKP IVISGPSGVG KGTLIAKLMK EYPSKFGFSV SHTTRAPREK EIDGVHYHFT
ERSKIEEEIS EGKFLEFAHV HGNVYGTSVE AVESVTDEGK RCILDIDVQG ARSVRASSLE
AIFIFVCPPS FEELEKRLRA RGTETEEQIQ KRLRNARAEL DQSNSPGLFD HLLVNDDLEA
CYENLKKLLS LDDDHEDSND SFIKDGKETA CYSILSKTNS EILLQSETNE AEKGTTNLLS
LDLSLSGGAP GRTRGLKISP VN
