ID   AMP2_TAROF              Reviewed;          44 AA.
AC   B3EWQ2;
DT   03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 1.
DT   25-MAY-2022, entry version 8.
DE   RecName: Full=Antimicrobial peptide 2 {ECO:0000303|PubMed:22640720};
DE            Short=ToAMP2 {ECO:0000303|PubMed:22640720};
OS   Taraxacum officinale (Common dandelion) (Leontodon taraxacum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae;
OC   Crepidinae; Taraxacum.
OX   NCBI_TaxID=50225;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, TISSUE SPECIFICITY, DISULFIDE BOND, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Sepal {ECO:0000269|PubMed:22640720};
RX   PubMed=22640720; DOI=10.1016/j.peptides.2012.05.009;
RA   Astafieva A.A., Rogozhin E.A., Odintsova T.I., Khadeeva N.V., Grishin E.V.,
RA   Egorov T.S.A.;
RT   "Discovery of novel antimicrobial peptides with unusual cysteine motifs in
RT   dandelion Taraxacum officinale Wigg. flowers.";
RL   Peptides 36:266-271(2012).
CC   -!- FUNCTION: Antimicrobial peptide. Active against fungal species
CC       B.cinerea (IC(50)=5.2 uM), A.niger (IC(50)=2.6 uM) and B.sorokinina
CC       (IC(50)=5.2 uM) but not against F.oxysporum, F.graminearum and
CC       P.debaryanum at concentrations below 10 uM. Inhibits growth of
CC       P.infestans at concentration between 1.3 uM and 5.2 uM. Active against
CC       bacterial species P.syringae, B.subtilis, X.campestris and
CC       C.michiganense. {ECO:0000269|PubMed:22640720}.
CC   -!- TISSUE SPECIFICITY: Expressed in flowers but not in leaves, seeds or
CC       roots (at protein level). {ECO:0000269|PubMed:22640720}.
CC   -!- PTM: Disulfide bonds. {ECO:0000269|PubMed:22640720}.
CC   -!- MASS SPECTROMETRY: Mass=4818.3; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:22640720};
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DR   AlphaFoldDB; B3EWQ2; -.
DR   SMR; B3EWQ2; -.
DR   GO; GO:0050832; P:defense response to fungus; IDA:UniProtKB.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Direct protein sequencing; Disulfide bond;
KW   Fungicide.
FT   PEPTIDE         1..44
FT                   /note="Antimicrobial peptide 2"
FT                   /evidence="ECO:0000269|PubMed:22640720"
FT                   /id="PRO_0000419498"
SQ   SEQUENCE   44 AA;  4827 MW;  39E7B6BFEB49EA4B CRC64;
     GGKCTVDWGG QGGGRRLPSP LFCCYKPTRI CYLNQETCET ETCP