GML_HUMAN
ID GML_HUMAN Reviewed; 158 AA.
AC Q99445; A0AVF6; O00686; O00731;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Glycosyl-phosphatidylinositol-anchored molecule-like protein;
DE Flags: Precursor;
GN Name=GML; Synonyms=LY6DL;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND INDUCTION BY TP53.
RX PubMed=8934543;
RA Furuhata T., Tokino T., Urano T., Nakamura Y.;
RT "Isolation of a novel GPI-anchored gene specifically regulated by p53;
RT correlation between its expression and anti-cancer drug sensitivity.";
RL Oncogene 13:1965-1970(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9169150; DOI=10.1006/geno.1997.4680;
RA Kimura Y., Furuhata T., Urano T., Hirata K., Nakamura Y., Tokino T.;
RT "Genomic structure and chromosomal localization of GML (GPI-anchored
RT molecule-like protein), a gene induced by p53.";
RL Genomics 41:477-480(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play a role in the apoptotic pathway or cell-cycle
CC regulation induced by p53/TP53 after DNA damage.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC anchor {ECO:0000305}.
CC -!- INDUCTION: By p53/TP53. {ECO:0000269|PubMed:8934543}.
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DR EMBL; D84290; BAA12300.1; -; mRNA.
DR EMBL; AB000381; BAA19961.1; -; Genomic_DNA.
DR EMBL; BC074930; AAH74930.1; -; mRNA.
DR EMBL; BC126336; AAI26337.1; -; mRNA.
DR EMBL; BC126338; AAI26339.1; -; mRNA.
DR CCDS; CCDS6391.1; -.
DR RefSeq; NP_002057.1; NM_002066.2.
DR AlphaFoldDB; Q99445; -.
DR BioGRID; 109027; 78.
DR IntAct; Q99445; 24.
DR STRING; 9606.ENSP00000220940; -.
DR TCDB; 9.A.71.1.1; the glycosylphosphatidylinositol-anchored protein (gpi-ap) family.
DR BioMuta; GML; -.
DR DMDM; 3183013; -.
DR MassIVE; Q99445; -.
DR PaxDb; Q99445; -.
DR PRIDE; Q99445; -.
DR Antibodypedia; 27797; 51 antibodies from 14 providers.
DR DNASU; 2765; -.
DR Ensembl; ENST00000220940.2; ENSP00000220940.1; ENSG00000104499.7.
DR GeneID; 2765; -.
DR KEGG; hsa:2765; -.
DR MANE-Select; ENST00000220940.2; ENSP00000220940.1; NM_002066.3; NP_002057.1.
DR UCSC; uc003yxg.3; human.
DR CTD; 2765; -.
DR DisGeNET; 2765; -.
DR GeneCards; GML; -.
DR HGNC; HGNC:4375; GML.
DR HPA; ENSG00000104499; Tissue enriched (adrenal).
DR MIM; 602370; gene.
DR neXtProt; NX_Q99445; -.
DR OpenTargets; ENSG00000104499; -.
DR PharmGKB; PA28760; -.
DR VEuPathDB; HostDB:ENSG00000104499; -.
DR eggNOG; ENOG502RU0V; Eukaryota.
DR GeneTree; ENSGT00940000159966; -.
DR HOGENOM; CLU_1668850_0_0_1; -.
DR InParanoid; Q99445; -.
DR OMA; YDIRRCM; -.
DR OrthoDB; 1532701at2759; -.
DR PhylomeDB; Q99445; -.
DR TreeFam; TF336908; -.
DR PathwayCommons; Q99445; -.
DR SignaLink; Q99445; -.
DR BioGRID-ORCS; 2765; 49 hits in 1069 CRISPR screens.
DR ChiTaRS; GML; human.
DR GenomeRNAi; 2765; -.
DR Pharos; Q99445; Tdark.
DR PRO; PR:Q99445; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q99445; protein.
DR Bgee; ENSG00000104499; Expressed in right adrenal gland cortex and 76 other tissues.
DR ExpressionAtlas; Q99445; baseline and differential.
DR Genevisible; Q99445; HS.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0019898; C:extrinsic component of membrane; TAS:ProtInc.
DR GO; GO:0005886; C:plasma membrane; TAS:ProtInc.
DR GO; GO:0006915; P:apoptotic process; TAS:ProtInc.
DR GO; GO:0006977; P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; TAS:ProtInc.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; TAS:ProtInc.
DR CDD; cd00117; LU; 1.
DR Gene3D; 2.10.60.10; -; 1.
DR InterPro; IPR018363; CD59_antigen_CS.
DR InterPro; IPR016054; LY6_UPA_recep-like.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR SMART; SM00134; LU; 1.
DR SUPFAM; SSF57302; SSF57302; 1.
DR PROSITE; PS00983; LY6_UPAR; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; GPI-anchor; Lipoprotein;
KW Membrane; Reference proteome; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..158
FT /note="Glycosyl-phosphatidylinositol-anchored molecule-like
FT protein"
FT /id="PRO_0000036166"
FT DOMAIN 29..134
FT /note="UPAR/Ly6"
FT DISULFID 31..55
FT /evidence="ECO:0000250"
FT DISULFID 34..42
FT /evidence="ECO:0000250"
FT DISULFID 48..73
FT /evidence="ECO:0000250"
FT DISULFID 77..104
FT /evidence="ECO:0000250"
FT DISULFID 105..110
FT /evidence="ECO:0000250"
FT VARIANT 54
FT /note="R -> C (in dbSNP:rs3764795)"
FT /id="VAR_020174"
SQ SEQUENCE 158 AA; 17730 MW; 21D7F23D33DBB3B2 CRC64;
MLLFALLLAM ELPLVAASAT MRAQWTYSLR CHDCAVINDF NCPNIRVCPY HIRRCMTISI
RINSRELLVY KNCTNNCTFV YAAEQPPEAP GKIFKTNSFY WVCCCNSMVC NAGGPTNLER
DMLPDEVTEE ELPEGTVRLG VSKLLLSFAS IIVSNILP
