ID   GMPAA_DANRE             Reviewed;         422 AA.
AC   Q6GMK8;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Mannose-1-phosphate guanyltransferase alpha-A;
DE            EC=2.7.7.13;
DE   AltName: Full=GDP-mannose pyrophosphorylase A-A;
DE   AltName: Full=GTP-mannose-1-phosphate guanylyltransferase subunit alpha-A;
GN   Name=gmppaa; ORFNames=zgc:91853;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-
CC         alpha-D-mannose; Xref=Rhea:RHEA:15229, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57527,
CC         ChEBI:CHEBI:58409; EC=2.7.7.13;
CC   -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose
CC       biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP
CC       route): step 1/1.
CC   -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family.
CC       {ECO:0000305}.
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DR   EMBL; BC074036; AAH74036.1; -; mRNA.
DR   RefSeq; NP_001002196.1; NM_001002196.1.
DR   AlphaFoldDB; Q6GMK8; -.
DR   SMR; Q6GMK8; -.
DR   STRING; 7955.ENSDARP00000017348; -.
DR   PaxDb; Q6GMK8; -.
DR   Ensembl; ENSDART00000178966; ENSDARP00000143324; ENSDARG00000024112.
DR   GeneID; 431743; -.
DR   KEGG; dre:431743; -.
DR   CTD; 431743; -.
DR   ZFIN; ZDB-GENE-040704-37; gmppaa.
DR   eggNOG; KOG1460; Eukaryota.
DR   GeneTree; ENSGT00940000157018; -.
DR   HOGENOM; CLU_029499_3_0_1; -.
DR   InParanoid; Q6GMK8; -.
DR   OMA; MPVPNWW; -.
DR   PhylomeDB; Q6GMK8; -.
DR   TreeFam; TF300832; -.
DR   UniPathway; UPA00126; UER00930.
DR   PRO; PR:Q6GMK8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 9.
DR   Bgee; ENSDARG00000024112; Expressed in testis and 27 other tissues.
DR   ExpressionAtlas; Q6GMK8; baseline.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009298; P:GDP-mannose biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR001451; Hexapep.
DR   InterPro; IPR018357; Hexapep_transf_CS.
DR   InterPro; IPR005835; NTP_transferase_dom.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   Pfam; PF00132; Hexapep; 1.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
DR   PROSITE; PS00101; HEXAPEP_TRANSFERASES; 1.
PE   2: Evidence at transcript level;
KW   GTP-binding; Nucleotide-binding; Nucleotidyltransferase;
KW   Reference proteome; Transferase.
FT   CHAIN           1..422
FT                   /note="Mannose-1-phosphate guanyltransferase alpha-A"
FT                   /id="PRO_0000327876"
SQ   SEQUENCE   422 AA;  47011 MW;  7A7986D2599C7E4C CRC64;
     MLKAVILIGG PQKGTRFRPL SFEVPKPLFP VAGVPMLQHH IEACSKLPNM KEILLIGFYQ
     PNEELNRFLS CAQQDFKISI RYLQEYAALG TGGGIYHFRD QILSGGPDAF FVMNADVCSE
     FPLPEMLDFQ KEHGDTYSFV ILGTTANRKQ SLNYGCIVEN EQTDEVLHYV EKPGTFVSDI
     INCGIYLFTP EIFQHIGSVF QKNQQEMLLE EQSNGWHRAE VIRLEQDIFT ALAGQGKLYV
     YKTDRFWSQI KSAGSAIYAS RLYLNQYHKT HPERLATNTE GGAKTRGNVY IHPTANIDPT
     AVLGPNVSIG TGVTIGAGVR VRESIILHGA TLQDHSCVLN SIVGWESTIG KWARVEGTPS
     DPNPNDPYAK IDSETLFRDG KLTPSITILG CNVNIPSEVI ILNSIVLPHK DLNRSFKNQI
     IL