ID   GMPAA_XENLA             Reviewed;         421 AA.
AC   Q6DKE9;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Mannose-1-phosphate guanyltransferase alpha-A;
DE            EC=2.7.7.13;
DE   AltName: Full=GDP-mannose pyrophosphorylase A-A;
DE   AltName: Full=GTP-mannose-1-phosphate guanylyltransferase subunit alpha-A;
GN   Name=gmppa-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-
CC         alpha-D-mannose; Xref=Rhea:RHEA:15229, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57527,
CC         ChEBI:CHEBI:58409; EC=2.7.7.13;
CC   -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose
CC       biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP
CC       route): step 1/1.
CC   -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family.
CC       {ECO:0000305}.
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DR   EMBL; BC074119; AAH74119.1; -; mRNA.
DR   RefSeq; NP_001086043.1; NM_001092574.1.
DR   AlphaFoldDB; Q6DKE9; -.
DR   SMR; Q6DKE9; -.
DR   DNASU; 444472; -.
DR   GeneID; 444472; -.
DR   KEGG; xla:444472; -.
DR   CTD; 444472; -.
DR   OrthoDB; 806744at2759; -.
DR   UniPathway; UPA00126; UER00930.
DR   Proteomes; UP000186698; Chromosome 9_10S.
DR   Bgee; 444472; Expressed in testis and 19 other tissues.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009298; P:GDP-mannose biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR001451; Hexapep.
DR   InterPro; IPR018357; Hexapep_transf_CS.
DR   InterPro; IPR005835; NTP_transferase_dom.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   Pfam; PF00132; Hexapep; 1.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
DR   PROSITE; PS00101; HEXAPEP_TRANSFERASES; 1.
PE   2: Evidence at transcript level;
KW   GTP-binding; Nucleotide-binding; Nucleotidyltransferase;
KW   Reference proteome; Transferase.
FT   CHAIN           1..421
FT                   /note="Mannose-1-phosphate guanyltransferase alpha-A"
FT                   /id="PRO_0000327878"
SQ   SEQUENCE   421 AA;  46452 MW;  73FDF1F98DCDF577 CRC64;
     MLKAVILIGG PQKGTRFRPL SFEVPKPLFP VAGVPMVQHH IEACSKVPNL KEILLIGFYQ
     PNEALNSFLL KAQQEFKVAI RYLQEYSALG TGGGIYHFRD QILSGGPQAF FVMNADVCSE
     FPLVSMLDFH KQHGGSQSYV ILGTTANRTQ SLNYGCIVAN RDTQEVLHYV EKPGTFVSDI
     INCGIYLFSP SIFQHIAEVF QQNQQELQLE ENSSWQRMEV IRLEQDVFST LAGRGKLYVY
     KTEGCWSQIK SAGSAIYASR LYLSQYGTTH PERLASTKEG GPTIRGNVYI HPTANVDPSA
     VLGPNVSIGM GVTVAAGVRI RESIILHGAV LQDHSCVLNT IVGWDSMVGR WARVEGTPSD
     PNPNDPYSKI DSETLFRDGK LTPSITILGC NVSIPAEVVI LNSIVLPHKE LSRSFKNQII
     L