ID   GMPAB_DANRE             Reviewed;         422 AA.
AC   Q7SXP8;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Mannose-1-phosphate guanyltransferase alpha-B;
DE            EC=2.7.7.13;
DE   AltName: Full=GDP-mannose pyrophosphorylase A-B;
DE   AltName: Full=GTP-mannose-1-phosphate guanylyltransferase alpha-b;
GN   Name=gmppab; ORFNames=zgc:66135;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-
CC         alpha-D-mannose; Xref=Rhea:RHEA:15229, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57527,
CC         ChEBI:CHEBI:58409; EC=2.7.7.13;
CC   -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose
CC       biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP
CC       route): step 1/1.
CC   -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family.
CC       {ECO:0000305}.
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DR   EMBL; BC055506; AAH55506.1; -; mRNA.
DR   RefSeq; NP_956791.1; NM_200497.1.
DR   AlphaFoldDB; Q7SXP8; -.
DR   SMR; Q7SXP8; -.
DR   STRING; 7955.ENSDARP00000032669; -.
DR   PaxDb; Q7SXP8; -.
DR   GeneID; 393469; -.
DR   KEGG; dre:393469; -.
DR   CTD; 393469; -.
DR   ZFIN; ZDB-GENE-040426-1550; gmppab.
DR   eggNOG; KOG1460; Eukaryota.
DR   InParanoid; Q7SXP8; -.
DR   OrthoDB; 806744at2759; -.
DR   PhylomeDB; Q7SXP8; -.
DR   UniPathway; UPA00126; UER00930.
DR   PRO; PR:Q7SXP8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009298; P:GDP-mannose biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR001451; Hexapep.
DR   InterPro; IPR018357; Hexapep_transf_CS.
DR   InterPro; IPR005835; NTP_transferase_dom.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   Pfam; PF00132; Hexapep; 1.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
DR   PROSITE; PS00101; HEXAPEP_TRANSFERASES; 1.
PE   2: Evidence at transcript level;
KW   GTP-binding; Nucleotide-binding; Nucleotidyltransferase;
KW   Reference proteome; Transferase.
FT   CHAIN           1..422
FT                   /note="Mannose-1-phosphate guanyltransferase alpha-B"
FT                   /id="PRO_0000327877"
SQ   SEQUENCE   422 AA;  47008 MW;  78090F1CE2D03698 CRC64;
     MLKAIILIGG PQKGTRFRPL SFEVPKPLFP VAGVPMLQHH IEACAQVPDM KEIMLIGFYQ
     PNDELNRFIY SAQQEFKIPI RYLQEFAALG TGGGIYHFRD QILSGGPAAF FLMNADVCSE
     FPLLEMLQFH RQHGENHCGV LLGTTANRTQ SLNYGCIVEN HETNEVLHFV EKPSTFVSDI
     INCGIYLFTP DIFAHIGKVF QRNQQEKIQE ELTHGRQMPE VVRLEQDIFT ALAGQKKLFV
     YKTQHFWSQI KSAGSAIYAS RLYLKQYHQT HPERLATNQG GTPKITGDVY IHPTANIDPS
     AVLGPNVSIG KGVTIGGGVR VRESIILHGA VLQDHCCVLN SIVGWDSTVG KWARVEGTPS
     DPNPNDPYAK IDSETLFRDG GLTPSITILG CNVNIPSEVI IRNSIVLPHK DLNRSFKNQI
     IL