ID   GMPAB_XENLA             Reviewed;         426 AA.
AC   Q66KG5;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Mannose-1-phosphate guanyltransferase alpha-B;
DE            EC=2.7.7.13;
DE   AltName: Full=GDP-mannose pyrophosphorylase A-B;
DE   AltName: Full=GTP-mannose-1-phosphate guanylyltransferase alpha-b;
GN   Name=gmppa-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-
CC         alpha-D-mannose; Xref=Rhea:RHEA:15229, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57527,
CC         ChEBI:CHEBI:58409; EC=2.7.7.13;
CC   -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose
CC       biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP
CC       route): step 1/1.
CC   -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family.
CC       {ECO:0000305}.
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DR   EMBL; BC080405; AAH80405.1; -; mRNA.
DR   RefSeq; NP_001087596.1; NM_001094127.1.
DR   AlphaFoldDB; Q66KG5; -.
DR   SMR; Q66KG5; -.
DR   MaxQB; Q66KG5; -.
DR   DNASU; 447420; -.
DR   GeneID; 447420; -.
DR   KEGG; xla:447420; -.
DR   CTD; 447420; -.
DR   OrthoDB; 806744at2759; -.
DR   UniPathway; UPA00126; UER00930.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 447420; Expressed in testis and 19 other tissues.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009298; P:GDP-mannose biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR001451; Hexapep.
DR   InterPro; IPR018357; Hexapep_transf_CS.
DR   InterPro; IPR005835; NTP_transferase_dom.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   Pfam; PF00132; Hexapep; 1.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
DR   PROSITE; PS00101; HEXAPEP_TRANSFERASES; 1.
PE   2: Evidence at transcript level;
KW   GTP-binding; Nucleotide-binding; Nucleotidyltransferase;
KW   Reference proteome; Transferase.
FT   CHAIN           1..426
FT                   /note="Mannose-1-phosphate guanyltransferase alpha-B"
FT                   /id="PRO_0000327879"
SQ   SEQUENCE   426 AA;  46884 MW;  5CA6C5D4872C1828 CRC64;
     MLKAVILIGG PQKGTRFRPL SFEVPKPLFP VAGVPMVQHH IEACSKVPNL KEILLIGFYQ
     PNEALSSFLL KAQQEFKVAI RYLQEYSALG TGGGIYHFRD QILSGGPQAF FVMNADVCSE
     FPLVPMLDFH KQHGGSQSYV ILGTTANRTQ SLNYGCIVSN GDTQEVLHYV EKPGTFVSDI
     INCGIYLFSP SIFQHIAEVF QRNQLELQLF SCISEENSSW QRTEVIRLEQ DVFTTLAGHG
     KLYVYKTEGC WSQIKSAGSA IYASRLYLSQ YSTTHPERLA STKEGGPTIR GNVYIHPTAN
     VDPSAVLGPN VSVGMGVTVG AGVRIRESII LHGAVLQDHS CVLNTIVGWD SMVGRWARVE
     GTPSDPNPND PYSKIDSETL FREGKLTPSI TILGCNVSIP AEVVILNSIV LPHKELSRSF
     KNQIIL