ID   GMPBA_XENLA             Reviewed;         360 AA.
AC   Q68EY9;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Mannose-1-phosphate guanyltransferase beta-A;
DE            EC=2.7.7.13;
DE   AltName: Full=GDP-mannose pyrophosphorylase B-A;
DE   AltName: Full=GTP-mannose-1-phosphate guanylyltransferase beta-A;
GN   Name=gmppb-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-
CC         alpha-D-mannose; Xref=Rhea:RHEA:15229, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57527,
CC         ChEBI:CHEBI:58409; EC=2.7.7.13;
CC   -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose
CC       biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP
CC       route): step 1/1.
CC   -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family.
CC       {ECO:0000305}.
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DR   EMBL; BC080059; AAH80059.1; -; mRNA.
DR   RefSeq; NP_001087522.1; NM_001094053.1.
DR   AlphaFoldDB; Q68EY9; -.
DR   SMR; Q68EY9; -.
DR   DNASU; 447346; -.
DR   GeneID; 447346; -.
DR   KEGG; xla:447346; -.
DR   CTD; 447346; -.
DR   Xenbase; XB-GENE-922662; gmppb.L.
DR   UniPathway; UPA00126; UER00930.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 447346; Expressed in liver and 19 other tissues.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009298; P:GDP-mannose biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd06425; M1P_guanylylT_B_like_N; 1.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR045233; GMPPB_N.
DR   InterPro; IPR001451; Hexapep.
DR   InterPro; IPR018357; Hexapep_transf_CS.
DR   InterPro; IPR005835; NTP_transferase_dom.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   Pfam; PF00132; Hexapep; 1.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
DR   PROSITE; PS00101; HEXAPEP_TRANSFERASES; 1.
PE   2: Evidence at transcript level;
KW   GTP-binding; Nucleotide-binding; Nucleotidyltransferase;
KW   Reference proteome; Transferase.
FT   CHAIN           1..360
FT                   /note="Mannose-1-phosphate guanyltransferase beta-A"
FT                   /id="PRO_0000307166"
SQ   SEQUENCE   360 AA;  40152 MW;  6F43FEF9844183FE CRC64;
     MKALILVGGY GTRLRPLTLS VPKPLVDFCN KPILLHQVEA LVKAGVTHVI LAVSYMSDML
     EKEMKEQEKR LGIRISMSHE KEPLGTAGPL ALARELLTEN SEPFFVLNSD VICDFPFEDM
     VRFHKHHGKE GTIVVTKVEE PSKYGVVVYE TESGQIQRFV EKPQVFVSNK INSGLYIFSP
     AVLDRIQLRP TSIEKEIFPA MAQEGQLYAM ELQGFWMDIG QPKDFLTGMC MYLQSVRQKH
     PEWLHAGPGF IGNVLVDPTA KIGQNCSIGP NVTIGPGVTV EDGVRIKRCT VMKGSRLHSH
     SWLESSIVGW SSSVGQWVRM ENVTVLGEDV IVNDELYLNG ANVLPHKCIS ESVPEPRIIM