ID   GMPBB_XENLA             Reviewed;         360 AA.
AC   A2VD83;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Mannose-1-phosphate guanyltransferase beta-B;
DE            EC=2.7.7.13 {ECO:0000250|UniProtKB:P0C5I2};
DE   AltName: Full=GDP-mannose pyrophosphorylase B-B;
DE   AltName: Full=GTP-mannose-1-phosphate guanylyltransferase beta-B;
GN   Name=gmppb-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Intestine;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the formation of GDP-mannose, an essential
CC       precursor of glycan moieties of glycoproteins and glycolipids.
CC       {ECO:0000250|UniProtKB:P0C5I2}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-
CC         alpha-D-mannose; Xref=Rhea:RHEA:15229, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57527,
CC         ChEBI:CHEBI:58409; EC=2.7.7.13;
CC         Evidence={ECO:0000250|UniProtKB:P0C5I2};
CC   -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose
CC       biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP
CC       route): step 1/1. {ECO:0000250|UniProtKB:P0C5I2}.
CC   -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family.
CC       {ECO:0000305}.
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DR   EMBL; BC129595; AAI29596.1; -; mRNA.
DR   RefSeq; NP_001091347.1; NM_001097878.1.
DR   RefSeq; XP_018114729.1; XM_018259240.1.
DR   AlphaFoldDB; A2VD83; -.
DR   SMR; A2VD83; -.
DR   DNASU; 100037186; -.
DR   GeneID; 100037186; -.
DR   KEGG; xla:100037186; -.
DR   CTD; 100037186; -.
DR   Xenbase; XB-GENE-6255238; gmppb.S.
DR   UniPathway; UPA00126; UER00930.
DR   Proteomes; UP000186698; Chromosome 4S.
DR   Bgee; 100037186; Expressed in neurula embryo and 18 other tissues.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009298; P:GDP-mannose biosynthetic process; ISS:UniProtKB.
DR   CDD; cd06425; M1P_guanylylT_B_like_N; 1.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR045233; GMPPB_N.
DR   InterPro; IPR001451; Hexapep.
DR   InterPro; IPR018357; Hexapep_transf_CS.
DR   InterPro; IPR005835; NTP_transferase_dom.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   Pfam; PF00132; Hexapep; 1.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
DR   PROSITE; PS00101; HEXAPEP_TRANSFERASES; 1.
PE   2: Evidence at transcript level;
KW   GTP-binding; Nucleotide-binding; Nucleotidyltransferase;
KW   Reference proteome; Transferase.
FT   CHAIN           1..360
FT                   /note="Mannose-1-phosphate guanyltransferase beta-B"
FT                   /id="PRO_0000307167"
SQ   SEQUENCE   360 AA;  40152 MW;  4B319B7BD4B58C4B CRC64;
     MKALILVGGY GTRLRPLTLS VPKPLVDFCN KPILLHQVEA LVKAGVTHVI LAVSYMSDML
     EKEMKEQEKR LGIRISMSHE KEPLGTAGPL ALARELLTEN SEPFFVLNSD VICDFPFEDM
     VRFHKHHGKE GTIVVTKVEE PSKYGVVIYE AESGRIQRFV EKPQVFVSNK INSGLYIFSP
     AVLDRIQLRP TSIEKEIFPV MAQEGQLFAL ELQGFWMDIG QPKDFLTGMC MYLQSVRHKH
     PERLHVGPGF TGNVLVDPTA KIGQNCSIGP NVTIGPGVTV EDGVRIKRCS IMKGSRLHSH
     SWLQSSIVGW SSSVGQWVRM ENVTVLGEDV IVNDELYLNG ANVLPHKCIS ESVPEPRIIM