ID   GMPPA_DICDI             Reviewed;         412 AA.
AC   Q86HG0; Q55AH7;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=Mannose-1-phosphate guanyltransferase alpha;
DE   AltName: Full=GDP-mannose pyrophosphorylase A;
DE   AltName: Full=GTP-mannose-1-phosphate guanylyltransferase alpha;
GN   Name=gmppA; Synonyms=mpgB; ORFNames=DDB_G0271858;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family.
CC       {ECO:0000305}.
CC   -!- CAUTION: GMPPA is a close homolog of GMPPB, that has been shown to
CC       catalyze the formation of GDP-mannose, an essential precursor of glycan
CC       moieties of glycoproteins and glycolipids. It has been hypothesized
CC       that GMPPA might serve as a regulatory subunit and allow allosteric
CC       feedback inhibition of GMPPB by GDP-mannose. Alignment of GMPPAs and
CC       GMPPBs from various species shows that GMPPAs are characterized by a 2
CC       amino acid-insertion (residues 11-12) in a highly conserved motif that
CC       borders the catalytic pocket and binds the nucleotide substrate in
CC       homologous enzymes. This insertion might inactivate the ancestral
CC       catalytic site, converting it to an allosteric site. {ECO:0000305}.
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DR   EMBL; AAFI02000007; EAL71508.1; -; Genomic_DNA.
DR   RefSeq; XP_645432.1; XM_640340.1.
DR   AlphaFoldDB; Q86HG0; -.
DR   SMR; Q86HG0; -.
DR   STRING; 44689.DDB0231666; -.
DR   PaxDb; Q86HG0; -.
DR   EnsemblProtists; EAL71508; EAL71508; DDB_G0271858.
DR   GeneID; 8618172; -.
DR   KEGG; ddi:DDB_G0271858; -.
DR   dictyBase; DDB_G0271858; gmppA.
DR   eggNOG; KOG1460; Eukaryota.
DR   HOGENOM; CLU_029499_3_0_1; -.
DR   InParanoid; Q86HG0; -.
DR   OMA; MPVPNWW; -.
DR   PhylomeDB; Q86HG0; -.
DR   PRO; PR:Q86HG0; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase activity; ISS:dictyBase.
DR   GO; GO:0009298; P:GDP-mannose biosynthetic process; ISS:dictyBase.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR001451; Hexapep.
DR   InterPro; IPR018357; Hexapep_transf_CS.
DR   InterPro; IPR005835; NTP_transferase_dom.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   Pfam; PF00132; Hexapep; 1.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
DR   PROSITE; PS00101; HEXAPEP_TRANSFERASES; 2.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..412
FT                   /note="Mannose-1-phosphate guanyltransferase alpha"
FT                   /id="PRO_0000328172"
SQ   SEQUENCE   412 AA;  45979 MW;  E1D2AF97E00AE1CE CRC64;
     MTTTTTKAII LVGGPSKGTR FRPLSLDVPK LLFPIAGKPM IYHHIEACSK VENMKEIILI
     GFFQESVLSK FISETSKQLN VAIRYINEEK VLGTAGGLYH FRDIILEGGP SEIFVLHSDI
     CCAFPLNDLL QFHKQHGRSC TIMGTEIESA YANQYGCLVR DEKTAELLHY AEKPETFVSN
     LINCGVYCFS PQFFDVIGKT MIDLKTSGQN ITTDYPEITR KGFDVERLRL EQDIFVPLAG
     TGFISVYPYV GFWRQIKNAG SSVYCQELYL NHFAKTKPEV LKKGNNIIGN VIIDSTASVD
     PSAIIGPDVY IGPNVKIGKG VRVIHSIILD QTEIKDHACI IYSIIGWQSL IGVWARIEGI
     PNYTPFLYSQ DKRRGVTIFG AGAQANGEII VSNCIVMPHK QLDRNYNNEI IL