ID   GMPPB_BOVIN             Reviewed;         360 AA.
AC   Q2YDJ9;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Mannose-1-phosphate guanyltransferase beta;
DE            EC=2.7.7.13 {ECO:0000250|UniProtKB:P0C5I2};
DE   AltName: Full=GDP-mannose pyrophosphorylase B;
DE   AltName: Full=GTP-mannose-1-phosphate guanylyltransferase beta;
GN   Name=GMPPB {ECO:0000250|UniProtKB:Q9Y5P6};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the formation of GDP-mannose, an essential
CC       precursor of glycan moieties of glycoproteins and glycolipids.
CC       {ECO:0000250|UniProtKB:P0C5I2}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-
CC         alpha-D-mannose; Xref=Rhea:RHEA:15229, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57527,
CC         ChEBI:CHEBI:58409; EC=2.7.7.13;
CC         Evidence={ECO:0000250|UniProtKB:P0C5I2};
CC   -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose
CC       biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP
CC       route): step 1/1. {ECO:0000250|UniProtKB:P0C5I2}.
CC   -!- SUBUNIT: Associates with GMPPA. {ECO:0000250|UniProtKB:P0C5I2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC110188; AAI10189.1; -; mRNA.
DR   RefSeq; NP_001039633.1; NM_001046168.2.
DR   AlphaFoldDB; Q2YDJ9; -.
DR   SMR; Q2YDJ9; -.
DR   STRING; 9913.ENSBTAP00000015403; -.
DR   PaxDb; Q2YDJ9; -.
DR   PeptideAtlas; Q2YDJ9; -.
DR   PRIDE; Q2YDJ9; -.
DR   GeneID; 514161; -.
DR   KEGG; bta:514161; -.
DR   CTD; 29925; -.
DR   eggNOG; KOG1322; Eukaryota.
DR   InParanoid; Q2YDJ9; -.
DR   OrthoDB; 806744at2759; -.
DR   SABIO-RK; Q2YDJ9; -.
DR   UniPathway; UPA00126; UER00930.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase activity; IBA:GO_Central.
DR   GO; GO:0016779; F:nucleotidyltransferase activity; IBA:GO_Central.
DR   GO; GO:0009298; P:GDP-mannose biosynthetic process; ISS:UniProtKB.
DR   GO; GO:0006486; P:protein glycosylation; IBA:GO_Central.
DR   CDD; cd06425; M1P_guanylylT_B_like_N; 1.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR045233; GMPPB_N.
DR   InterPro; IPR001451; Hexapep.
DR   InterPro; IPR018357; Hexapep_transf_CS.
DR   InterPro; IPR005835; NTP_transferase_dom.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   Pfam; PF00132; Hexapep; 1.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
DR   PROSITE; PS00101; HEXAPEP_TRANSFERASES; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; GTP-binding; Nucleotide-binding; Nucleotidyltransferase;
KW   Reference proteome; Transferase.
FT   CHAIN           1..360
FT                   /note="Mannose-1-phosphate guanyltransferase beta"
FT                   /id="PRO_0000307161"
SQ   SEQUENCE   360 AA;  39837 MW;  5C240179793A8712 CRC64;
     MKALILVGGY GTRLRPLTLS IPKPLADFCN KPILLHQVEA LAAAGVDHVI LAVSYMSQVL
     EKEMKAQEQK LGIRISMSHE EEPLGTAGPL ALARDLLCET ADPFFVLNSD VICDFPFEAM
     VQFHRHHGQE GSILVTKVEE PSKYGVVVCE ADTGRVHRFV EKPQVFVSNK INAGVYILSP
     SVLRRIQLQP TSIEKEIFPV MAKEGQLYAM ELQGFWMDIG QPKDFLTGMC LFLKSLRQKH
     PEQLCSGPGI VGNVLVDPRA RIGENCSIGP NVSLGPGVVV EDGVCIRRCT VLRDAHIRSH
     SWLESCIVGW RCRVGQWVRM ENVTVLGEDV IVNDELYLNG ASVLPHKSIG ESVPEPRIIM