ID   GMPPB_CAEBR             Reviewed;         364 AA.
AC   Q61S97; A8X0H9;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 2.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Mannose-1-phosphate guanyltransferase beta;
DE            EC=2.7.7.13;
DE   AltName: Full=GDP-mannose pyrophosphorylase B;
DE   AltName: Full=GTP-mannose-1-phosphate guanylyltransferase beta;
GN   Name=tag-335; ORFNames=CBG06266;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-
CC         alpha-D-mannose; Xref=Rhea:RHEA:15229, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57527,
CC         ChEBI:CHEBI:58409; EC=2.7.7.13;
CC   -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose
CC       biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP
CC       route): step 1/1.
CC   -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family.
CC       {ECO:0000305}.
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DR   EMBL; HE600986; CAP26139.2; -; Genomic_DNA.
DR   AlphaFoldDB; Q61S97; -.
DR   SMR; Q61S97; -.
DR   STRING; 6238.CBG06266; -.
DR   EnsemblMetazoa; CBG06266.1; CBG06266.1; WBGene00028569.
DR   WormBase; CBG06266; CBP34494; WBGene00028569; Cbr-tag-335.
DR   eggNOG; KOG1322; Eukaryota.
DR   HOGENOM; CLU_029499_0_0_1; -.
DR   InParanoid; Q61S97; -.
DR   OMA; PFLTHQL; -.
DR   OrthoDB; 806744at2759; -.
DR   UniPathway; UPA00126; UER00930.
DR   Proteomes; UP000008549; Chromosome IV.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase activity; IBA:GO_Central.
DR   GO; GO:0016779; F:nucleotidyltransferase activity; IBA:GO_Central.
DR   GO; GO:0000032; P:cell wall mannoprotein biosynthetic process; IBA:GO_Central.
DR   GO; GO:0009298; P:GDP-mannose biosynthetic process; IBA:GO_Central.
DR   GO; GO:0006486; P:protein glycosylation; IBA:GO_Central.
DR   CDD; cd06425; M1P_guanylylT_B_like_N; 1.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR045233; GMPPB_N.
DR   InterPro; IPR001451; Hexapep.
DR   InterPro; IPR018357; Hexapep_transf_CS.
DR   InterPro; IPR005835; NTP_transferase_dom.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   Pfam; PF00132; Hexapep; 1.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
DR   PROSITE; PS00101; HEXAPEP_TRANSFERASES; 1.
PE   3: Inferred from homology;
KW   GTP-binding; Nucleotide-binding; Nucleotidyltransferase;
KW   Reference proteome; Transferase.
FT   CHAIN           1..364
FT                   /note="Mannose-1-phosphate guanyltransferase beta"
FT                   /id="PRO_0000307169"
SQ   SEQUENCE   364 AA;  39800 MW;  E0A3A4DE5C38321A CRC64;
     MKALILVGGY GTRLRPLTLT QPKPLVEFAN KPMMLHQMEA LAAVGVDTVV LAVSYRAEQL
     EAEMTVHADR LGVKLIFSLE EEPLGTAGPL ALARKHLEDD DPFFVLNSDV ICDFPFKQMV
     EFHKQHGKEG TIAVTKVEEP SKYGVVVFKE DGKIDDFVEK PQEYVGNKIN AGLYIFNSAI
     LDRIPLKPTS IEKEIFPQMA TSGNLYAYVL PGFWMDVGQP KDFLKGMSLF LNHVQTTRTG
     ALATGSNIHG TATIRGSVLV DPSATVGENC VIGPDVVIGP RVQIEGGVRI QHSTILSDST
     VGNYSWVSGS IIGRECHIGS WVRMENVCVL GDDVVVKDEV YLNEASVLPH KVIAVNVPSK
     DIIM