ID   GMPPB_CAEEL             Reviewed;         365 AA.
AC   A3QMC8;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Mannose-1-phosphate guanyltransferase beta;
DE            EC=2.7.7.13;
DE   AltName: Full=GDP-mannose pyrophosphorylase B;
DE   AltName: Full=GTP-mannose-1-phosphate guanylyltransferase beta;
GN   Name=tag-335; ORFNames=C42C1.5;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-
CC         alpha-D-mannose; Xref=Rhea:RHEA:15229, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57527,
CC         ChEBI:CHEBI:58409; EC=2.7.7.13;
CC   -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose
CC       biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP
CC       route): step 1/1.
CC   -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family.
CC       {ECO:0000305}.
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DR   EMBL; CU457741; CAM36360.1; -; Genomic_DNA.
DR   RefSeq; NP_502333.2; NM_069932.5.
DR   AlphaFoldDB; A3QMC8; -.
DR   SMR; A3QMC8; -.
DR   BioGRID; 48228; 4.
DR   STRING; 6239.C42C1.5; -.
DR   EPD; A3QMC8; -.
DR   PaxDb; A3QMC8; -.
DR   PeptideAtlas; A3QMC8; -.
DR   EnsemblMetazoa; C42C1.5.1; C42C1.5.1; WBGene00016583.
DR   EnsemblMetazoa; C42C1.5.2; C42C1.5.2; WBGene00016583.
DR   GeneID; 183400; -.
DR   KEGG; cel:CELE_C42C1.5; -.
DR   UCSC; C42C1.5; c. elegans.
DR   CTD; 183400; -.
DR   WormBase; C42C1.5; CE40443; WBGene00016583; tag-335.
DR   eggNOG; KOG1322; Eukaryota.
DR   GeneTree; ENSGT00940000158909; -.
DR   HOGENOM; CLU_029499_0_0_1; -.
DR   InParanoid; A3QMC8; -.
DR   OMA; PFLTHQL; -.
DR   OrthoDB; 806744at2759; -.
DR   PhylomeDB; A3QMC8; -.
DR   UniPathway; UPA00126; UER00930.
DR   PRO; PR:A3QMC8; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00016583; Expressed in adult organism and 4 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase activity; IBA:GO_Central.
DR   GO; GO:0016779; F:nucleotidyltransferase activity; IBA:GO_Central.
DR   GO; GO:0000032; P:cell wall mannoprotein biosynthetic process; IBA:GO_Central.
DR   GO; GO:0009298; P:GDP-mannose biosynthetic process; IBA:GO_Central.
DR   GO; GO:0006486; P:protein glycosylation; IBA:GO_Central.
DR   CDD; cd06425; M1P_guanylylT_B_like_N; 1.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR045233; GMPPB_N.
DR   InterPro; IPR001451; Hexapep.
DR   InterPro; IPR018357; Hexapep_transf_CS.
DR   InterPro; IPR005835; NTP_transferase_dom.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   Pfam; PF00132; Hexapep; 1.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
DR   PROSITE; PS00101; HEXAPEP_TRANSFERASES; 1.
PE   3: Inferred from homology;
KW   GTP-binding; Nucleotide-binding; Nucleotidyltransferase;
KW   Reference proteome; Transferase.
FT   CHAIN           1..365
FT                   /note="Mannose-1-phosphate guanyltransferase beta"
FT                   /id="PRO_0000307170"
SQ   SEQUENCE   365 AA;  40099 MW;  95D21189EB6984F2 CRC64;
     MKALILVGGY GTRLRPLTLT QPKPLVEFAN KPMMLHQMEA LAEVGVDTVV LAVSYRAEQL
     EQEMTVHADR LGVKLIFSLE EEPLGTAGPL ALARKHLEGD APFFVLNSDV ICDFPFKQMV
     EFHKNHGKEG TIAVTKVEEP SKYGVVVFDQ DKGKIDDFVE KPQEYVGNKI NAGLYIFSSK
     ILDRIPLKPT SIEKEIFPEM AFSGNLYAFV LPGFWMDVGQ PKDFLKGMSL FLNHCHTTKS
     DKLETGSNIH PTATIRGNVM VDPSATVGEN CVIGPDVVIG PRVKIEGGVR ILHSTILSDS
     SIGNYSWVSG SIVGRKCHIG SWVRIENICV IGDDVVVKDE LYLNGASVLP HKSIAVNVPS
     KDIIM