GMPPB_DROME
ID GMPPB_DROME Reviewed; 369 AA.
AC Q7JZB4;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Mannose-1-phosphate guanyltransferase beta;
DE EC=2.7.7.13;
DE AltName: Full=GDP-mannose pyrophosphorylase B;
DE AltName: Full=GTP-mannose-1-phosphate guanylyltransferase beta;
GN ORFNames=CG1129;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo, and Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-
CC alpha-D-mannose; Xref=Rhea:RHEA:15229, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57527,
CC ChEBI:CHEBI:58409; EC=2.7.7.13;
CC -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose
CC biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP
CC route): step 1/1.
CC -!- INTERACTION:
CC Q7JZB4; Q8SXU3: Dmel\CG8207; NbExp=6; IntAct=EBI-165604, EBI-101652;
CC -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family.
CC {ECO:0000305}.
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DR EMBL; AE014297; AAG22216.1; -; Genomic_DNA.
DR EMBL; AY061013; AAL28561.1; -; mRNA.
DR EMBL; AY071411; AAL49033.1; -; mRNA.
DR RefSeq; NP_001189177.2; NM_001202248.2.
DR RefSeq; NP_001287164.1; NM_001300235.1.
DR RefSeq; NP_649498.1; NM_141241.4.
DR RefSeq; NP_730877.1; NM_169021.4.
DR AlphaFoldDB; Q7JZB4; -.
DR SMR; Q7JZB4; -.
DR BioGRID; 65815; 20.
DR IntAct; Q7JZB4; 2.
DR STRING; 7227.FBpp0078510; -.
DR SwissPalm; Q7JZB4; -.
DR PaxDb; Q7JZB4; -.
DR PRIDE; Q7JZB4; -.
DR DNASU; 40599; -.
DR EnsemblMetazoa; FBtr0078870; FBpp0078510; FBgn0037279.
DR EnsemblMetazoa; FBtr0078871; FBpp0078511; FBgn0037279.
DR EnsemblMetazoa; FBtr0345174; FBpp0311383; FBgn0037279.
DR EnsemblMetazoa; FBtr0345175; FBpp0311384; FBgn0037279.
DR GeneID; 40599; -.
DR KEGG; dme:Dmel_CG1129; -.
DR UCSC; CG1129-RA; d. melanogaster.
DR FlyBase; FBgn0037279; CG1129.
DR VEuPathDB; VectorBase:FBgn0037279; -.
DR eggNOG; KOG1322; Eukaryota.
DR GeneTree; ENSGT00940000158909; -.
DR HOGENOM; CLU_029499_0_0_1; -.
DR InParanoid; Q7JZB4; -.
DR OMA; PFLTHQL; -.
DR OrthoDB; 806744at2759; -.
DR PhylomeDB; Q7JZB4; -.
DR UniPathway; UPA00126; UER00930.
DR BioGRID-ORCS; 40599; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 40599; -.
DR PRO; PR:Q7JZB4; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0037279; Expressed in saliva-secreting gland and 35 other tissues.
DR ExpressionAtlas; Q7JZB4; baseline and differential.
DR Genevisible; Q7JZB4; DM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase activity; ISS:FlyBase.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IBA:GO_Central.
DR GO; GO:0000032; P:cell wall mannoprotein biosynthetic process; IBA:GO_Central.
DR GO; GO:0009298; P:GDP-mannose biosynthetic process; IBA:GO_Central.
DR GO; GO:0035167; P:larval lymph gland hemopoiesis; IMP:FlyBase.
DR GO; GO:0006486; P:protein glycosylation; IBA:GO_Central.
DR CDD; cd06425; M1P_guanylylT_B_like_N; 1.
DR Gene3D; 3.90.550.10; -; 1.
DR InterPro; IPR045233; GMPPB_N.
DR InterPro; IPR001451; Hexapep.
DR InterPro; IPR018357; Hexapep_transf_CS.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR Pfam; PF00132; Hexapep; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF53448; SSF53448; 1.
DR PROSITE; PS00101; HEXAPEP_TRANSFERASES; 2.
PE 1: Evidence at protein level;
KW GTP-binding; Nucleotide-binding; Nucleotidyltransferase;
KW Reference proteome; Transferase.
FT CHAIN 1..369
FT /note="Mannose-1-phosphate guanyltransferase beta"
FT /id="PRO_0000307171"
SQ SEQUENCE 369 AA; 40448 MW; F70675F39B3683F0 CRC64;
MCGNPAVGNG TRALILVGGY GTRLRPLTLS TPKPLVEFAN KPILLHQLEA LVDAGCRQVI
LAVSYRAEQM EKELKVEAKK LGVELIFSHE TEPLGTAGPL ALAKTILAAS SEPFFVLNSD
VICDFPFKQL VQFHCNHGKE GTIVVTKVEE PSKYGVVLYD ENGCIKNFIE KPQEFVSNKI
NAGIYIFNPS VLDRIEVKPT SIEKEVFPEM TQQQELYAMD LTGFWMDIGQ PKDFLTGMCL
YLSSLRQKQS PKLYTGPGVV GNVLVDPTAK IGEGCRIGPN VTIGPDVVIE DGVCIKRSTI
LKGAIVRSHS WLDSCIVGWR STVGRWVRIE GITVLGEDVI VKDELYINGG QVLPHKSIAA
SVPEPQIIM
