ID   GMPPB_DROPS             Reviewed;         371 AA.
AC   Q295Y7;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Mannose-1-phosphate guanyltransferase beta;
DE            EC=2.7.7.13;
DE   AltName: Full=GDP-mannose pyrophosphorylase B;
DE   AltName: Full=GTP-mannose-1-phosphate guanylyltransferase beta;
GN   ORFNames=GA10892;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-
CC         alpha-D-mannose; Xref=Rhea:RHEA:15229, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57527,
CC         ChEBI:CHEBI:58409; EC=2.7.7.13;
CC   -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose
CC       biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP
CC       route): step 1/1.
CC   -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family.
CC       {ECO:0000305}.
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DR   EMBL; CM000070; EAL28571.1; -; Genomic_DNA.
DR   RefSeq; XP_001359425.1; XM_001359388.4.
DR   AlphaFoldDB; Q295Y7; -.
DR   SMR; Q295Y7; -.
DR   STRING; 7237.FBpp0281507; -.
DR   EnsemblMetazoa; FBtr0378365; FBpp0339192; FBgn0070948.
DR   GeneID; 4802517; -.
DR   KEGG; dpo:Dpse_GA10892; -.
DR   eggNOG; KOG1322; Eukaryota.
DR   HOGENOM; CLU_029499_0_0_1; -.
DR   InParanoid; Q295Y7; -.
DR   OMA; PFLTHQL; -.
DR   PhylomeDB; Q295Y7; -.
DR   UniPathway; UPA00126; UER00930.
DR   Proteomes; UP000001819; Chromosome 2.
DR   Bgee; FBgn0070948; Expressed in female reproductive system and 3 other tissues.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009298; P:GDP-mannose biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0035167; P:larval lymph gland hemopoiesis; IEA:EnsemblMetazoa.
DR   CDD; cd06425; M1P_guanylylT_B_like_N; 1.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR045233; GMPPB_N.
DR   InterPro; IPR001451; Hexapep.
DR   InterPro; IPR018357; Hexapep_transf_CS.
DR   InterPro; IPR005835; NTP_transferase_dom.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   Pfam; PF00132; Hexapep; 1.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
DR   PROSITE; PS00101; HEXAPEP_TRANSFERASES; 2.
PE   3: Inferred from homology;
KW   GTP-binding; Nucleotide-binding; Nucleotidyltransferase;
KW   Reference proteome; Transferase.
FT   CHAIN           1..371
FT                   /note="Mannose-1-phosphate guanyltransferase beta"
FT                   /id="PRO_0000307172"
SQ   SEQUENCE   371 AA;  40603 MW;  FFB52C75F3AC9616 CRC64;
     MCGSPNTTVG NGTRALILVG GYGTRLRPLT LSTPKPLVEF ANKPILLHQL EALVDAGCRQ
     VILAVSYRAE QMEKELKVEA DKLGVELIFS HETEPLGTAG PLALAKSILS ASPEPFFVLN
     SDVICDFPFK QLVQFHRNHG KEGTIVVTKV EEPSKYGVVL YDEDGCIKNF IEKPQEFVSN
     KINAGIYIFN PSVLERIEVK PTSIEKEVFP AMAEQQELYA MDLTGFWMDI GQPKDFLTGM
     CLYLSSLRQK QSPKLYTGPG VVGNVLVDPT ATIGEGCRIG PNVTIGPDVI IEDGVCIKRA
     TILKGAIVRS HSWLDSCIVG WRSTVGRWVR IEGITVLGED VIVKDELYVN GGQVLPHKSI
     AASVPEPQII M