GMS1_SCHPO
ID GMS1_SCHPO Reviewed; 353 AA.
AC P87041; O59769;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2001, sequence version 3.
DT 25-MAY-2022, entry version 142.
DE RecName: Full=UDP-galactose transporter;
DE AltName: Full=Golgi UDP-Gal transporter;
GN Name=gms1; ORFNames=SPCC1795.03;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=TY741;
RX PubMed=10371208; DOI=10.1016/s0014-5793(99)00596-7;
RA Segawa H., Ishida N., Takegawa K., Kawakita M.;
RT "Schizosaccharomyces pombe UDP-galactose transporter: identification of its
RT functional form through cDNA cloning and expression in mammalian cells.";
RL FEBS Lett. 451:295-298(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 40-353.
RX PubMed=9125114; DOI=10.1006/bbrc.1997.6239;
RA Tabuchi M., Tanaka N., Iwahara S., Takegawa K.;
RT "The Schizosaccharomyces pombe gms1+ gene encodes an UDP-galactose
RT transporter homologue required for protein galactosylation.";
RL Biochem. Biophys. Res. Commun. 232:121-125(1997).
RN [4]
RP SEQUENCE REVISION TO 164-192.
RA Takegawa K.;
RL Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Essential for the transport of UDP-galactose into the lumen
CC of Golgi apparatus.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane; Multi-pass membrane
CC protein.
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35A
CC subfamily. {ECO:0000305}.
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DR EMBL; AB023425; BAA77219.1; -; mRNA.
DR EMBL; CU329672; CAA18638.1; -; Genomic_DNA.
DR EMBL; D89616; BAA24703.1; -; Genomic_DNA.
DR PIR; T43506; T43506.
DR RefSeq; NP_588041.1; NM_001023033.2.
DR AlphaFoldDB; P87041; -.
DR SMR; P87041; -.
DR BioGRID; 275767; 25.
DR STRING; 4896.SPCC1795.03.1; -.
DR PaxDb; P87041; -.
DR EnsemblFungi; SPCC1795.03.1; SPCC1795.03.1:pep; SPCC1795.03.
DR GeneID; 2539196; -.
DR KEGG; spo:SPCC1795.03; -.
DR PomBase; SPCC1795.03; gms1.
DR VEuPathDB; FungiDB:SPCC1795.03; -.
DR eggNOG; KOG2234; Eukaryota.
DR HOGENOM; CLU_024645_1_0_1; -.
DR InParanoid; P87041; -.
DR OMA; AFFSVTM; -.
DR PhylomeDB; P87041; -.
DR Reactome; R-SPO-727802; Transport of nucleotide sugars.
DR PRO; PR:P87041; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0000139; C:Golgi membrane; EXP:PomBase.
DR GO; GO:0030173; C:integral component of Golgi membrane; IDA:PomBase.
DR GO; GO:0005459; F:UDP-galactose transmembrane transporter activity; IDA:PomBase.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0097624; P:UDP-galactose transmembrane import into Golgi lumen; IMP:PomBase.
DR GO; GO:0072334; P:UDP-galactose transmembrane transport; IDA:PomBase.
DR InterPro; IPR007271; Nuc_sug_transpt.
DR PANTHER; PTHR10231; PTHR10231; 1.
DR Pfam; PF04142; Nuc_sug_transp; 1.
DR PIRSF; PIRSF005799; UDP-gal_transpt; 1.
PE 2: Evidence at transcript level;
KW Golgi apparatus; Membrane; Reference proteome; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..353
FT /note="UDP-galactose transporter"
FT /id="PRO_0000213362"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..204
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 215..235
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 254..274
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 279..299
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 302..322
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 325..353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 325..339
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 353 AA; 39101 MW; F9B7D6DC09C8ADC5 CRC64;
MAVKGDDVKW KGIPMKYIAL VLLTVQNSAL ILTLNYSRIM PGYDDKRYFT STAVLLNELI
KLVVCFSVGY HQFRKNVGKE AKLRAFLPQI FGGDSWKLAI PAFLYTCQNN LQYVAAGNLT
AASFQVTYQL KILTTAIFSI LLLHRRLGPM KWFSLFLLTG GIAIVQLQNL NSDDQMSAGP
MNPVTGFSAV LVACLISGLA GVYFEKVLKD TNPSLWVRNV QLSFFSLFPC LFTILMKDYH
NIAENGFFFG YNSIVWLAIL LQAGGGIIVA LCVAFADNIM KNFSTSISII ISSLASVYLM
DFKISLTFLI GVMLVIAATF LYTKPESKPS PSRGTYIPMT TQDAAAKDVD HKH
