GMT2_CRYNJ
ID GMT2_CRYNJ Reviewed; 420 AA.
AC P0CS04; Q55P93; Q5KE63; Q5VJN4;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 49.
DE RecName: Full=GDP-mannose transporter 2;
DE Short=GMT 2;
GN Name=GMT2; Synonyms=VRG4-2; OrderedLocusNames=CNG01600;
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RX PubMed=17351078; DOI=10.1128/ec.00015-07;
RA Cottrell T.R., Griffith C.L., Liu H., Nenninger A.A., Doering T.L.;
RT "The pathogenic fungus Cryptococcus neoformans expresses two functional
RT GDP-mannose transporters with distinct expression patterns and roles in
RT capsule synthesis.";
RL Eukaryot. Cell 6:776-785(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565;
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: Involved in the import of GDP-mannose from the cytoplasm into
CC the Golgi lumen. {ECO:0000250, ECO:0000269|PubMed:17351078}.
CC -!- SUBUNIT: Homooligomer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic
CC reticulum membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TPT transporter family. SLC35D subfamily.
CC {ECO:0000305}.
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DR EMBL; AY428959; AAR96298.1; -; mRNA.
DR EMBL; AE017347; AAW44567.1; -; Genomic_DNA.
DR RefSeq; XP_571874.1; XM_571874.1.
DR AlphaFoldDB; P0CS04; -.
DR SMR; P0CS04; -.
DR STRING; 5207.AAW44567; -.
DR TCDB; 2.A.7.13.7; the drug/metabolite transporter (dmt) superfamily.
DR PaxDb; P0CS04; -.
DR EnsemblFungi; AAW44567; AAW44567; CNG01600.
DR GeneID; 3258778; -.
DR KEGG; cne:CNG01600; -.
DR VEuPathDB; FungiDB:CNG01600; -.
DR eggNOG; KOG1444; Eukaryota.
DR HOGENOM; CLU_025360_1_2_1; -.
DR InParanoid; P0CS04; -.
DR OMA; IQSTVCV; -.
DR OrthoDB; 1093260at2759; -.
DR PHI-base; PHI:3490; -.
DR Proteomes; UP000002149; Chromosome 7.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
DR GO; GO:0005458; F:GDP-mannose transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR InterPro; IPR013657; UAA.
DR InterPro; IPR038736; Vrg4-like.
DR PANTHER; PTHR11132:SF251; PTHR11132:SF251; 1.
DR Pfam; PF08449; UAA; 1.
PE 2: Evidence at transcript level;
KW Cytoplasmic vesicle; Endoplasmic reticulum; Golgi apparatus; Membrane;
KW Reference proteome; Sugar transport; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..420
FT /note="GDP-mannose transporter 2"
FT /id="PRO_0000333521"
FT TOPO_DOM 1..76
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 98..106
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 128..145
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 146..168
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..171
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 172..194
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 195..200
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 201..223
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 224..251
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 252..272
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 273..293
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 294..314
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 315..323
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 324..344
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 345..355
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 356..376
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 377..378
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 379..399
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 400..420
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 420 AA; 45250 MW; 412CD8ECEB2D848D CRC64;
MASYTPSSSR PHTPLGLSPR GSYTNLASAA YDASSPGGHG AKDEKERLRA EREVQEALLK
AQDGVEKAKK EEVCMPASTT VLPILSYCVA SIMMTVVNKF VVSGRQFTMT FLLLAIQSFV
CVACVWLAKR IGVINFRDWD MNDAKAWFPV SSLLVAVIYT GSKSLQFLSI PVYTIFKNLT
IILIAYGEVI WFGGHVTPLT LCSFFLMVGS SVIAAWADIS TTLSKLSAGV AVVDPISGAD
VPLSSISVMD TMNVGYLWMF INCLASAGYV LFMRKRIKVT GFKDWDSMFY NNLLSIPVLF
VFSLIIEDWG AASFSRNFPE EGRAFLLSAI AFSGAAAVFI SYSTAWCVRI CGATTYSLVG
ALNKLPVAAS GILFFGDPVN FGNVSAILVG GVSGIVYAVA KTNQAKVEKS KQARGGESKA
