ID   AMP3_TAROF              Reviewed;          42 AA.
AC   B3EWQ3;
DT   03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 1.
DT   25-MAY-2022, entry version 9.
DE   RecName: Full=Antimicrobial peptide 3 {ECO:0000303|PubMed:22640720};
DE            Short=ToAMP3 {ECO:0000303|PubMed:22640720};
OS   Taraxacum officinale (Common dandelion) (Leontodon taraxacum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae;
OC   Crepidinae; Taraxacum.
OX   NCBI_TaxID=50225;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, TISSUE SPECIFICITY, DISULFIDE BOND, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Sepal {ECO:0000269|PubMed:22640720};
RX   PubMed=22640720; DOI=10.1016/j.peptides.2012.05.009;
RA   Astafieva A.A., Rogozhin E.A., Odintsova T.I., Khadeeva N.V., Grishin E.V.,
RA   Egorov T.S.A.;
RT   "Discovery of novel antimicrobial peptides with unusual cysteine motifs in
RT   dandelion Taraxacum officinale Wigg. flowers.";
RL   Peptides 36:266-271(2012).
CC   -!- FUNCTION: Antimicrobial peptide. Active against fungal species
CC       F.oxysporum (IC(50)=5.7 uM) and A.niger (IC(50)=5.6 uM) but not against
CC       B.cinerea, F.graminearum, B.sorokinina and P.debaryanum at
CC       concentrations below 10 uM. Active against bacterial species
CC       P.syringae, B.subtilis and X.campestris. {ECO:0000269|PubMed:22640720}.
CC   -!- TISSUE SPECIFICITY: Expressed in flowers but not in leaves, seeds or
CC       roots (at protein level). {ECO:0000269|PubMed:22640720}.
CC   -!- PTM: Disulfide bonds. {ECO:0000269|PubMed:22640720}.
CC   -!- MASS SPECTROMETRY: Mass=4398.9; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:22640720};
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DR   AlphaFoldDB; B3EWQ3; -.
DR   GO; GO:0050832; P:defense response to fungus; IDA:UniProtKB.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Direct protein sequencing; Disulfide bond;
KW   Fungicide.
FT   PEPTIDE         1..42
FT                   /note="Antimicrobial peptide 3"
FT                   /evidence="ECO:0000269|PubMed:22640720"
FT                   /id="PRO_0000419499"
SQ   SEQUENCE   42 AA;  4409 MW;  4151FD6B61E2D8EC CRC64;
     ANKCIIDCMK VKTTCGDECK GAGFKTGGCA LPPDIMKCCH NC