GMT2_NEOFI
ID GMT2_NEOFI Reviewed; 357 AA.
AC A1DA52;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=GDP-mannose transporter 2;
DE Short=GMT 2;
GN Name=gmt2; Synonyms=vrg4-2; ORFNames=NFIA_031160;
OS Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=331117;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181
RC / WB 181;
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: Involved in the import of GDP-mannose from the cytoplasm into
CC the Golgi lumen. {ECO:0000250}.
CC -!- SUBUNIT: Homooligomer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic
CC reticulum membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TPT transporter family. SLC35D subfamily.
CC {ECO:0000305}.
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DR EMBL; DS027693; EAW20683.1; -; Genomic_DNA.
DR RefSeq; XP_001262580.1; XM_001262579.1.
DR AlphaFoldDB; A1DA52; -.
DR SMR; A1DA52; -.
DR STRING; 36630.CADNFIAP00002631; -.
DR EnsemblFungi; EAW20683; EAW20683; NFIA_031160.
DR GeneID; 4588960; -.
DR KEGG; nfi:NFIA_031160; -.
DR VEuPathDB; FungiDB:NFIA_031160; -.
DR eggNOG; KOG1444; Eukaryota.
DR HOGENOM; CLU_025360_1_2_1; -.
DR OMA; WCIRKTS; -.
DR OrthoDB; 1093260at2759; -.
DR Proteomes; UP000006702; Unassembled WGS sequence.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005458; F:GDP-mannose transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR InterPro; IPR038736; Vrg4-like.
DR PANTHER; PTHR11132:SF251; PTHR11132:SF251; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle; Endoplasmic reticulum; Glycoprotein; Golgi apparatus;
KW Membrane; Reference proteome; Sugar transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..357
FT /note="GDP-mannose transporter 2"
FT /id="PRO_0000333530"
FT TOPO_DOM 1..33
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 55..68
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 69..89
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 90..107
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 108..128
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 129
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 130..150
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 151..161
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 162..181
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 182..196
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 197..217
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 237..257
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..277
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 278..298
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 299..306
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 307..327
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 328..332
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 333..352
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 353..357
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT CARBOHYD 184
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 357 AA; 37923 MW; F6463B19A551E717 CRC64;
MASARNGVSK DELLPVYERR SQRDGDISGS VKSFASTIGN SASAAVLAYC LSSISMTLVN
KYVVSGASWN LSFLYLAMQS FIGTVAILAC KKTGLIQNLA LFDLKKAQTW LPISLLLVGM
IYTGNKALQF LSVPVYTIFK NLTIIVIAYG EVLMVGGGVK PLALLSFGLM VLSSVVAAWA
DIQNATTATV GASSDSTAAA LSALNAGYAW MGTNVIFSAS YALGMRRVIK KTNFDNWDVM
FYNNLLSIPI LLLASVLAED WSSENLQRNF PAELRQSLFI GILYSGVAAV FISYCTAWCV
RATSSTTYAM VGALNKLPLA VAGIVFFAAP VTFGSVSAIV LGFISGLVYA RAKSTGA
