GMT2_YEAS8
ID GMT2_YEAS8 Reviewed; 341 AA.
AC C8Z742;
DT 02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 03-NOV-2009, sequence version 1.
DT 25-MAY-2022, entry version 47.
DE RecName: Full=Probable GDP-mannose transporter 2;
DE Short=GMT 2;
GN Name=HVG1; Synonyms=YEM9; ORFNames=EC1118_1E8_1442g;
OS Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse) (Baker's
OS yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=643680;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Lalvin EC1118 / Prise de mousse;
RX PubMed=19805302; DOI=10.1073/pnas.0904673106;
RA Novo M., Bigey F., Beyne E., Galeote V., Gavory F., Mallet S., Cambon B.,
RA Legras J.-L., Wincker P., Casaregola S., Dequin S.;
RT "Eukaryote-to-eukaryote gene transfer events revealed by the genome
RT sequence of the wine yeast Saccharomyces cerevisiae EC1118.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:16333-16338(2009).
CC -!- FUNCTION: Involved in the import of GDP-mannose from the cytoplasm into
CC the Golgi lumen. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic
CC reticulum membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250}. Note=Recycles between the Golgi apparatus and the
CC endoplasmic reticulum. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TPT transporter family. SLC35D subfamily.
CC {ECO:0000305}.
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DR EMBL; FN393067; CAY79208.1; -; Genomic_DNA.
DR AlphaFoldDB; C8Z742; -.
DR SMR; C8Z742; -.
DR EnsemblFungi; CAY79208; CAY79208; EC1118_1E8_1420g.
DR HOGENOM; CLU_025360_1_2_1; -.
DR Proteomes; UP000000286; Chromosome V, Scaffold EC1118_1E8.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005458; F:GDP-mannose transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR InterPro; IPR000620; EamA_dom.
DR InterPro; IPR038736; Vrg4-like.
DR PANTHER; PTHR11132:SF251; PTHR11132:SF251; 1.
DR Pfam; PF00892; EamA; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle; Endoplasmic reticulum; Glycoprotein; Golgi apparatus;
KW Membrane; Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..341
FT /note="Probable GDP-mannose transporter 2"
FT /id="PRO_0000391665"
FT TOPO_DOM 1..11
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 33..46
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 47..67
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 68..85
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 107
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 108..128
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 129..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..176
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 198..214
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 215..235
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 236..251
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 252..272
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 273..278
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 279..299
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 300..303
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 304..324
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 325..341
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT CARBOHYD 241
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 245
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 341 AA; 38049 MW; E4E46B359C640D37 CRC64;
MSKHKHEWTE SVANSGPASI LSYCASSILM TVTNKFVVNL DNFNMNFVML FVQSLVCTVT
LCILRIVGVA NFRSLNRTDV KNWFPISLLL VLMIYTSLKS LQYLAVPIYT IFKNLTIILI
AYGEVLFFGG KVTSMELTSF IMMVLSSVVA TWGDQQAIAI KASSLEDLDQ ELVESTIFVL
NPGYLWMFTN CISSALFVLI MRKRIRLTNF KDYDTMFYNN VLALPLLLVF SFIMEDWSTK
NLSVNLSADS LAAMVISGLM SVGISYCSGW CVRVTSSTTY SMVGALNKLP IALAGLVFFD
APKNFLSFFS IFLGFLSGLL YAVAKQKKIQ QQKVLAATLE K
