GMT_ASPOR
ID GMT_ASPOR Reviewed; 381 AA.
AC Q2UTL1;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 2.
DT 25-MAY-2022, entry version 84.
DE RecName: Full=GDP-mannose transporter;
DE Short=GMT;
GN Name=gmt1; Synonyms=vrg4; ORFNames=AO090009000688;
OS Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=510516;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42149 / RIB 40;
RX PubMed=16372010; DOI=10.1038/nature04300;
RA Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA Kikuchi H.;
RT "Genome sequencing and analysis of Aspergillus oryzae.";
RL Nature 438:1157-1161(2005).
CC -!- FUNCTION: Involved in the import of GDP-mannose from the cytoplasm into
CC the Golgi lumen. {ECO:0000250}.
CC -!- SUBUNIT: Homooligomer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic
CC reticulum membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TPT transporter family. SLC35D subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE55104.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AP007150; BAE55104.1; ALT_INIT; Genomic_DNA.
DR RefSeq; XP_001817106.2; XM_001817054.2.
DR AlphaFoldDB; Q2UTL1; -.
DR SMR; Q2UTL1; -.
DR STRING; 510516.Q2UTL1; -.
DR EnsemblFungi; BAE55104; BAE55104; AO090009000688.
DR GeneID; 5989036; -.
DR KEGG; aor:AO090009000688; -.
DR VEuPathDB; FungiDB:AO090009000688; -.
DR Proteomes; UP000006564; Chromosome 1.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005458; F:GDP-mannose transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR InterPro; IPR038736; Vrg4-like.
DR PANTHER; PTHR11132:SF251; PTHR11132:SF251; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle; Endoplasmic reticulum; Golgi apparatus; Membrane;
KW Reference proteome; Sugar transport; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..381
FT /note="GDP-mannose transporter"
FT /id="PRO_0000333512"
FT TOPO_DOM 1..39
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 61..68
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 69..89
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 90..109
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 110..126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 127..133
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 134..150
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 151..159
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 160..181
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 182..199
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 200..220
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..232
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 254..273
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 274..294
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 295..302
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 303..323
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 324..326
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 327..347
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 348..381
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
SQ SEQUENCE 381 AA; 41469 MW; F72C69CF4B10C609 CRC64;
MVESKKTDDY AIEMDKIDQG SKNFEAAAPP QPRSVPSSSL SGNPVLPVLA YCGSSILMTV
MNKYVLSGLD FNLNFFLLCV QSIVCIIAIQ TCKFCGLITY RDFSADEAKK WFPISLLLIG
MIYTGSKALQ FLSIPVYTIF KNLTIILIAY GEVLWFGGSV TGLTLFSFGL MVLSSIIAAW
ADIKHAVESS GDTSAQVSTL NAGYIWMLIN CLCTSSYVLG MRKRIKLTNF KDFDTMFYNN
LLSIPVLVVL TGLMEDWSSA NIDRNFPQAD RSSIMFAMIL SGLSSVFISY TSAWCVRVTS
STTYSMVGAL NKLPIALSGL IFFDAPVTFP SVSAIAVGFV SGIVYAIAKI KQNAKPKTGV
LPTSNPLVSA SSQSMRDSLR S
