GMT_CANGA
ID GMT_CANGA Reviewed; 324 AA.
AC Q6FRE5; Q96X08;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=GDP-mannose transporter;
DE Short=GMT;
GN Name=VRG4; OrderedLocusNames=CAGL0H09196g;
OS Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS Y-65) (Yeast) (Torulopsis glabrata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC Nakaseomyces/Candida clade.
OX NCBI_TaxID=284593;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC STRAIN=BG2;
RX PubMed=12185838; DOI=10.1002/yea.854;
RA Nishikawa A., Mendez B., Jigami Y., Dean N.;
RT "Identification of a Candida glabrata homologue of the S. cerevisiae VRG4
RT gene, encoding the Golgi GDP-mannose transporter.";
RL Yeast 19:691-698(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Involved in the import of GDP-mannose from the cytoplasm into
CC the Golgi lumen. {ECO:0000269|PubMed:12185838}.
CC -!- SUBUNIT: Homooligomer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic
CC reticulum membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TPT transporter family. SLC35D subfamily.
CC {ECO:0000305}.
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DR EMBL; AF360395; AAK51897.1; -; Genomic_DNA.
DR EMBL; CR380954; CAG60132.1; -; Genomic_DNA.
DR RefSeq; XP_447199.1; XM_447199.1.
DR AlphaFoldDB; Q6FRE5; -.
DR SMR; Q6FRE5; -.
DR STRING; 5478.XP_447199.1; -.
DR EnsemblFungi; CAG60132; CAG60132; CAGL0H09196g.
DR GeneID; 2888653; -.
DR KEGG; cgr:CAGL0H09196g; -.
DR CGD; CAL0129728; VRG4.
DR VEuPathDB; FungiDB:CAGL0H09196g; -.
DR eggNOG; KOG1444; Eukaryota.
DR HOGENOM; CLU_025360_1_2_1; -.
DR InParanoid; Q6FRE5; -.
DR OMA; IQSTVCV; -.
DR Proteomes; UP000002428; Chromosome H.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005458; F:GDP-mannose transmembrane transporter activity; IEA:EnsemblFungi.
DR GO; GO:0005338; F:nucleotide-sugar transmembrane transporter activity; IGI:CGD.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0006487; P:protein N-linked glycosylation; IGI:CGD.
DR InterPro; IPR038736; Vrg4-like.
DR PANTHER; PTHR11132:SF251; PTHR11132:SF251; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle; Endoplasmic reticulum; Glycoprotein; Golgi apparatus;
KW Membrane; Reference proteome; Sugar transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..324
FT /note="GDP-mannose transporter"
FT /id="PRO_0000333516"
FT TOPO_DOM 1..13
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 14..34
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 35..44
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 66..76
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 98..116
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..170
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 192..204
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 205..225
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 226..243
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 265..270
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 271..291
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..295
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 296..316
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 317..324
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT CARBOHYD 116
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 168
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 237
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 312
FT /note="S -> L (in Ref. 1; AAK51897)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 324 AA; 35761 MW; 98112C674B320566 CRC64;
MSELKSRIGN SGSIANSGPV SILCYCASSI LMTVTNKFVV NTDGFNMFFV MLFAQSLVCT
MCLMVLKMFG YAKYRPLNLI DVKNWLPISF LLVFMIFTSA KALKYMPVPI YTIFKNLTII
LIAYGEVLFF GGSVTPMELS SFILMVLSSV VASLGDQQAA KIAQPLANNS ILSPEYYWMF
LNCICSASFV LIMRKRIKLT NFKDYDTMFY NNALALPILL GFSFLSEDWS SENLAQNFSG
ESLSAMIISG MTSVGISYCS GWCVRATSST TYSMVGALNK LPIALAGLIF FDAPRNFLSI
MSIFIGFASG LSYAVAKQKK VQKN
