ID   GMT_CHAGB               Reviewed;         394 AA.
AC   Q2HA88;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 2.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=GDP-mannose transporter;
DE            Short=GMT;
GN   Name=VRG4; ORFNames=CHGG_02866;
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS   NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=306901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX   PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
CC   -!- FUNCTION: Involved in the import of GDP-mannose from the cytoplasm into
CC       the Golgi lumen. {ECO:0000250}.
CC   -!- SUBUNIT: Homooligomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane
CC       {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic
CC       reticulum membrane {ECO:0000250}; Multi-pass membrane protein
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TPT transporter family. SLC35D subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAQ90931.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CH408030; EAQ90931.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001229382.1; XM_001229381.1.
DR   AlphaFoldDB; Q2HA88; -.
DR   SMR; Q2HA88; -.
DR   STRING; 38033.XP_001229382.1; -.
DR   EnsemblFungi; EAQ90931; EAQ90931; CHGG_02866.
DR   GeneID; 4389796; -.
DR   eggNOG; KOG1444; Eukaryota.
DR   HOGENOM; CLU_025360_1_2_1; -.
DR   InParanoid; Q2HA88; -.
DR   OrthoDB; 1093260at2759; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005458; F:GDP-mannose transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   InterPro; IPR038736; Vrg4-like.
DR   PANTHER; PTHR11132:SF251; PTHR11132:SF251; 1.
PE   3: Inferred from homology;
KW   Cytoplasmic vesicle; Endoplasmic reticulum; Golgi apparatus; Membrane;
KW   Reference proteome; Sugar transport; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..394
FT                   /note="GDP-mannose transporter"
FT                   /id="PRO_0000333517"
FT   TOPO_DOM        1..56
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        57..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        78..81
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        103..122
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        123..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        146..150
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        151..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        169..174
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        175..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        200..207
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        208..228
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        229..249
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        250..270
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        271..288
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        289..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        310..317
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        318..338
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        339..341
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        342..362
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        363..394
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   394 AA;  42705 MW;  58DF22F56A24C5B9 CRC64;
     MSNKKNEDIE MRAVEGANDF GGEKDPFLGR NSPVLRPRGR EPTASAYFGK LDNSPGASII
     AYCLSSISMT VVNKYVVSGE SWNLNFFYLG VQSLVCTIAI LLSRQTGLIK NLAPFDSNKA
     KRWFPVSLLL VSMIYTGANA LQYLSVPVYT IFKNLTIIVI AYGEVLWFGG SVTPLMLLSF
     GLMVLSSVVA AWADIQAAID GVGHSAETSA ALATLNAGYA WMGLNVVCTS SYLLGMRKVI
     KKMNFKDYDS MFYNNLLTIP VLVVCSLLVE DWSSENLAKN FPIETRNKLM VGMIYSGLAA
     IFISYCSAWC IRVTSSTTYS MVGALNKLPI AISGLIFFDA PITFGSITAI AVGFVSGLVF
     AWAKVRQKAQ EAGLLPTTKP TMSASAQSNR DANS