GMT_COPC7
ID GMT_COPC7 Reviewed; 360 AA.
AC A8N9T6;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 2.
DT 25-MAY-2022, entry version 65.
DE RecName: Full=GDP-mannose transporter;
DE Short=GMT;
GN Name=VRG4; ORFNames=CC1G_05663;
OS Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)
OS (Inky cap fungus) (Hormographiella aspergillata).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Psathyrellaceae; Coprinopsis.
OX NCBI_TaxID=240176;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003;
RX PubMed=20547848; DOI=10.1073/pnas.1003391107;
RA Stajich J.E., Wilke S.K., Ahren D., Au C.H., Birren B.W., Borodovsky M.,
RA Burns C., Canbaeck B., Casselton L.A., Cheng C.K., Deng J., Dietrich F.S.,
RA Fargo D.C., Farman M.L., Gathman A.C., Goldberg J., Guigo R., Hoegger P.J.,
RA Hooker J.B., Huggins A., James T.Y., Kamada T., Kilaru S., Kodira C.,
RA Kuees U., Kupfer D., Kwan H.S., Lomsadze A., Li W., Lilly W.W., Ma L.-J.,
RA Mackey A.J., Manning G., Martin F., Muraguchi H., Natvig D.O.,
RA Palmerini H., Ramesh M.A., Rehmeyer C.J., Roe B.A., Shenoy N., Stanke M.,
RA Ter-Hovhannisyan V., Tunlid A., Velagapudi R., Vision T.J., Zeng Q.,
RA Zolan M.E., Pukkila P.J.;
RT "Insights into evolution of multicellular fungi from the assembled
RT chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus).";
RL Proc. Natl. Acad. Sci. U.S.A. 107:11889-11894(2010).
CC -!- FUNCTION: Involved in the import of GDP-mannose from the cytoplasm into
CC the Golgi lumen. {ECO:0000250}.
CC -!- SUBUNIT: Homooligomer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic
CC reticulum membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TPT transporter family. SLC35D subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAU90125.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AACS02000007; EAU90125.2; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_001831592.2; XM_001831540.2.
DR AlphaFoldDB; A8N9T6; -.
DR SMR; A8N9T6; -.
DR STRING; 240176.A8N9T6; -.
DR EnsemblFungi; EAU90125; EAU90125; CC1G_05663.
DR GeneID; 6008064; -.
DR KEGG; cci:CC1G_05663; -.
DR HOGENOM; CLU_025360_1_2_1; -.
DR InParanoid; A8N9T6; -.
DR OrthoDB; 1093260at2759; -.
DR Proteomes; UP000001861; Unassembled WGS sequence.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005458; F:GDP-mannose transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR InterPro; IPR013657; UAA.
DR InterPro; IPR038736; Vrg4-like.
DR PANTHER; PTHR11132:SF251; PTHR11132:SF251; 1.
DR Pfam; PF08449; UAA; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle; Endoplasmic reticulum; Golgi apparatus; Membrane;
KW Reference proteome; Sugar transport; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..360
FT /note="GDP-mannose transporter"
FT /id="PRO_0000333519"
FT TOPO_DOM 1..49
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 50..67
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 68..84
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 106..110
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 111..131
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 132..134
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 135..155
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 156..164
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 186
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 187..207
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 208..220
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 221..241
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 242..260
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 261..281
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 282..291
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 292..312
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 313..314
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 315..335
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 336..360
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
SQ SEQUENCE 360 AA; 38863 MW; 7F2374C65949AC4B CRC64;
MSSSETKGRN EEDVAEIKKA IATGAVKDPS NLSAIPPIFV VSGANFSMNF LLLCIQSSVC
CACVFAVKKL GIISFRDFDM KDAKMWFPIS FLLVSVIYTG SKSLQYLSIP VYTIFKNLTI
ILIAYGEVLW FGGRVTALTF VSFIFMVISS IIAAWSDVQS ALASSIPGAS SGVSVGAMQS
LFGALRGLNV GYFWMLVNCL TSAAYVLSMR KRIKSTGFSD WDTMFYNNLL SIPVLAVFSL
IAEDWGRENL NRNFPAETRN FLLFAIAFSG AAAVGISYTT AWCVRVTSST TYSMVGALNK
LPVAASGMLF FGDPVTVGSV SAVGVGFFAG IVYAVAKNNQ KKNERRQAAD AIIPMASRKP
