GMT_KLULA
ID GMT_KLULA Reviewed; 330 AA.
AC Q6CYD0;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=GDP-mannose transporter;
DE Short=GMT;
GN Name=VRG4; OrderedLocusNames=KLLA0A01364g;
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Involved in the import of GDP-mannose from the cytoplasm into
CC the Golgi lumen. {ECO:0000250}.
CC -!- SUBUNIT: Homooligomer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic
CC reticulum membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TPT transporter family. SLC35D subfamily.
CC {ECO:0000305}.
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DR EMBL; CR382121; CAH02647.1; -; Genomic_DNA.
DR RefSeq; XP_451059.1; XM_451059.1.
DR AlphaFoldDB; Q6CYD0; -.
DR SMR; Q6CYD0; -.
DR STRING; 28985.XP_451059.1; -.
DR EnsemblFungi; CAH02647; CAH02647; KLLA0_A01364g.
DR GeneID; 2896624; -.
DR KEGG; kla:KLLA0_A01364g; -.
DR eggNOG; KOG1444; Eukaryota.
DR HOGENOM; CLU_025360_1_2_1; -.
DR InParanoid; Q6CYD0; -.
DR OMA; IQSTVCV; -.
DR Proteomes; UP000000598; Chromosome A.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005458; F:GDP-mannose transmembrane transporter activity; IEA:EnsemblFungi.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR InterPro; IPR013657; UAA.
DR InterPro; IPR038736; Vrg4-like.
DR PANTHER; PTHR11132:SF251; PTHR11132:SF251; 1.
DR Pfam; PF08449; UAA; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle; Endoplasmic reticulum; Golgi apparatus; Membrane;
KW Reference proteome; Sugar transport; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..330
FT /note="GDP-mannose transporter"
FT /id="PRO_0000333524"
FT TOPO_DOM 1..13
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 14..34
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 35..48
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 70..81
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 82..98
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 99..104
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 105..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 125..138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 139..155
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 156..170
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 192..203
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 204..224
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 225..241
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 242..262
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 263..269
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 270..290
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..294
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 295..315
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 316..330
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
SQ SEQUENCE 330 AA; 36576 MW; E4144E025F234272 CRC64;
MSQLKVDNGP LSHVANSGPI SIGAYCFSSI MMTVTNKFVV NLKGFNMNFV MLFVQAAVCV
NLLFFLRLLG YAKFRPLNRT DAKNWFPITI FLVLMIYTSS KSLQYLAVPI YTIFKNLTII
LIAYGEVLFF GGSVTAMELS SFLLMVLSSV VATLGDQQAL KKTADAGASL FNIGYMWMFI
NCLSSAAFVL VMRKRIKLTN FKDFDTMFYN NILSMPVLLA LSFLMEDWST ENLTKNLSRD
SVTAMIISGM TAVCISYCSG WCVRVTSSTT YSMVGALNKL PIALSGLIFF DAPKNFLSIF
SIFLGFLSGI VYAVAKQKKQ QNPQPSAPIK
