GMT_LACBS
ID GMT_LACBS Reviewed; 340 AA.
AC B0DI84;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 1.
DT 25-MAY-2022, entry version 60.
DE RecName: Full=GDP-mannose transporter;
DE Short=GMT;
GN Name=VRG4; ORFNames=LACBIDRAFT_251779;
OS Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686) (Bicoloured deceiver)
OS (Laccaria laccata var. bicolor).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Tricholomataceae; Laccaria.
OX NCBI_TaxID=486041;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 / ATCC MYA-4686;
RX PubMed=18322534; DOI=10.1038/nature06556;
RA Martin F., Aerts A., Ahren D., Brun A., Danchin E.G.J., Duchaussoy F.,
RA Gibon J., Kohler A., Lindquist E., Pereda V., Salamov A., Shapiro H.J.,
RA Wuyts J., Blaudez D., Buee M., Brokstein P., Canbaeck B., Cohen D.,
RA Courty P.E., Coutinho P.M., Delaruelle C., Detter J.C., Deveau A.,
RA DiFazio S., Duplessis S., Fraissinet-Tachet L., Lucic E., Frey-Klett P.,
RA Fourrey C., Feussner I., Gay G., Grimwood J., Hoegger P.J., Jain P.,
RA Kilaru S., Labbe J., Lin Y.C., Legue V., Le Tacon F., Marmeisse R.,
RA Melayah D., Montanini B., Muratet M., Nehls U., Niculita-Hirzel H.,
RA Oudot-Le Secq M.P., Peter M., Quesneville H., Rajashekar B., Reich M.,
RA Rouhier N., Schmutz J., Yin T., Chalot M., Henrissat B., Kuees U.,
RA Lucas S., Van de Peer Y., Podila G.K., Polle A., Pukkila P.J.,
RA Richardson P.M., Rouze P., Sanders I.R., Stajich J.E., Tunlid A.,
RA Tuskan G., Grigoriev I.V.;
RT "The genome of Laccaria bicolor provides insights into mycorrhizal
RT symbiosis.";
RL Nature 452:88-92(2008).
CC -!- FUNCTION: Involved in the import of GDP-mannose from the cytoplasm into
CC the Golgi lumen. {ECO:0000250}.
CC -!- SUBUNIT: Homooligomer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic
CC reticulum membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TPT transporter family. SLC35D subfamily.
CC {ECO:0000305}.
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DR EMBL; DS547112; EDR05635.1; -; Genomic_DNA.
DR RefSeq; XP_001883739.1; XM_001883704.1.
DR AlphaFoldDB; B0DI84; -.
DR SMR; B0DI84; -.
DR STRING; 486041.B0DI84; -.
DR EnsemblFungi; EDR05635; EDR05635; LACBIDRAFT_251779.
DR GeneID; 6079272; -.
DR KEGG; lbc:LACBIDRAFT_251779; -.
DR HOGENOM; CLU_025360_1_2_1; -.
DR InParanoid; B0DI84; -.
DR OrthoDB; 1093260at2759; -.
DR Proteomes; UP000001194; Unassembled WGS sequence.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005458; F:GDP-mannose transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR InterPro; IPR038736; Vrg4-like.
DR PANTHER; PTHR11132:SF251; PTHR11132:SF251; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle; Endoplasmic reticulum; Golgi apparatus; Membrane;
KW Reference proteome; Sugar transport; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..340
FT /note="GDP-mannose transporter"
FT /id="PRO_0000333525"
FT TOPO_DOM 1..6
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 28..36
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 58..77
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 99..101
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..125
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 126..146
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 147..167
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 168..188
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 189..202
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 203..223
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 224..240
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 262..271
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..294
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 295..315
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 316..340
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
SQ SEQUENCE 340 AA; 36821 MW; E47EC7187BD92B3F CRC64;
MLNNNDIWSK VPPILCYCCA SILMTVVNKF VVSGAHFSMN FLLLCIQSTV CVVCVATVKK
FGIISFRSFD MQDAKAWFPI SFLLVTVIYT GSKSLQFLSI PVYTIFKNLT IILIAYGEVI
WFGGRVTALT FVSFIFMVIS SMIAAWSDVS SGLSGSVPAT IAGAVRGLNV GYFWMLVNCL
TSAAYVLAMR KRIKVTGFSD WDSMFYNNLL SIPVLAIFSI VVEDWGLENL GRNFPAETRS
FLLTAIAFSG AAAVGISYTT AWCVRTTSST TYSMVGALNK LPVAASGMLF FGDAVTFGSV
SAVGVGFFAG IVYAVAKNNQ KKTEGRLQAD AIIPLASRKP
