GMT_PHANO
ID GMT_PHANO Reviewed; 381 AA.
AC Q0UG89;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=GDP-mannose transporter;
DE Short=GMT;
GN Name=VRG4; ORFNames=SNOG_09225;
OS Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume
OS blotch fungus) (Parastagonospora nodorum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Phaeosphaeriaceae;
OC Parastagonospora.
OX NCBI_TaxID=321614;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SN15 / ATCC MYA-4574 / FGSC 10173;
RX PubMed=18024570; DOI=10.1105/tpc.107.052829;
RA Hane J.K., Lowe R.G.T., Solomon P.S., Tan K.-C., Schoch C.L.,
RA Spatafora J.W., Crous P.W., Kodira C.D., Birren B.W., Galagan J.E.,
RA Torriani S.F.F., McDonald B.A., Oliver R.P.;
RT "Dothideomycete-plant interactions illuminated by genome sequencing and EST
RT analysis of the wheat pathogen Stagonospora nodorum.";
RL Plant Cell 19:3347-3368(2007).
CC -!- FUNCTION: Involved in the import of GDP-mannose from the cytoplasm into
CC the Golgi lumen. {ECO:0000250}.
CC -!- SUBUNIT: Homooligomer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic
CC reticulum membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TPT transporter family. SLC35D subfamily.
CC {ECO:0000305}.
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DR EMBL; CH445338; EAT83417.1; -; Genomic_DNA.
DR RefSeq; XP_001799524.1; XM_001799472.1.
DR AlphaFoldDB; Q0UG89; -.
DR SMR; Q0UG89; -.
DR STRING; 13684.SNOT_09225; -.
DR EnsemblFungi; SNOT_09225; SNOT_09225; SNOG_09225.
DR GeneID; 5976425; -.
DR KEGG; pno:SNOG_09225; -.
DR eggNOG; KOG1444; Eukaryota.
DR HOGENOM; CLU_025360_1_2_1; -.
DR InParanoid; Q0UG89; -.
DR OMA; IQSTVCV; -.
DR OrthoDB; 1093260at2759; -.
DR Proteomes; UP000001055; Unassembled WGS sequence.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
DR GO; GO:0005458; F:GDP-mannose transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR InterPro; IPR038736; Vrg4-like.
DR PANTHER; PTHR11132:SF251; PTHR11132:SF251; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle; Endoplasmic reticulum; Golgi apparatus; Membrane;
KW Reference proteome; Sugar transport; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..381
FT /note="GDP-mannose transporter"
FT /id="PRO_0000333532"
FT TOPO_DOM 1..36
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 58..67
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 89..107
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 108..126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 127..130
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 131..153
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 154..161
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 162..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 185..199
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 200..220
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..242
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 243..263
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 264..274
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 275..295
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..303
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 304..324
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 325..327
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 328..348
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 349..381
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 381 AA; 41826 MW; 0C3B17DD8265B2BE CRC64;
MSDDKKSDDY RVDMPSSRTS RAPSPIMRPA LKSAPSLTEN PMAAVLAYCA SSILMTVTNK
YVLSGVDFNL NFFLLCVQSV VCVTAISICK AAGLITYRDF NTDEAKKWFP ISLLLIGMIY
TGTWALKYLS IPVYTIFKNL TIILIAYGEV LWFGGSVTPM TLFSFGLMVL SSIIAAWADI
QHALNSFGQQ SEAANEALST MHAGYLWMAF NCVCSATYLL SMRKRIKLTN FKDYDTMYYN
NLLTIPILLV ASILVEDWSS ANIQKNFPPE QRNTVIMVMV ISGMSTVFIS YTSAWAVRVT
SSTTYSMVGA LNKLPIAISG LVFFDAPVTF GSVSAIFVGF VSGIVYAVAK VRQNSKPKTV
LPTTNIPLSA SSRSMQDSLK A
