GMT_PICST
ID GMT_PICST Reviewed; 327 AA.
AC A3LWX1;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 1.
DT 25-MAY-2022, entry version 81.
DE RecName: Full=GDP-mannose transporter;
DE Short=GMT;
GN Name=VRG4; ORFNames=PICST_48772;
OS Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS Y-11545) (Yeast) (Pichia stipitis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX NCBI_TaxID=322104;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX PubMed=17334359; DOI=10.1038/nbt1290;
RA Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA Passoth V., Richardson P.M.;
RT "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT yeast Pichia stipitis.";
RL Nat. Biotechnol. 25:319-326(2007).
CC -!- FUNCTION: Involved in the import of GDP-mannose from the cytoplasm into
CC the Golgi lumen. {ECO:0000250}.
CC -!- SUBUNIT: Homooligomer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic
CC reticulum membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TPT transporter family. SLC35D subfamily.
CC {ECO:0000305}.
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DR EMBL; CP000500; ABN67707.1; -; Genomic_DNA.
DR RefSeq; XP_001385736.1; XM_001385699.1.
DR AlphaFoldDB; A3LWX1; -.
DR SMR; A3LWX1; -.
DR STRING; 4924.XP_001385736.1; -.
DR EnsemblFungi; ABN67707; ABN67707; PICST_48772.
DR GeneID; 4840002; -.
DR KEGG; pic:PICST_48772; -.
DR eggNOG; KOG1444; Eukaryota.
DR HOGENOM; CLU_025360_1_2_1; -.
DR InParanoid; A3LWX1; -.
DR OMA; IQSTVCV; -.
DR OrthoDB; 1093260at2759; -.
DR Proteomes; UP000002258; Chromosome 6.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005458; F:GDP-mannose transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR InterPro; IPR038736; Vrg4-like.
DR PANTHER; PTHR11132:SF251; PTHR11132:SF251; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle; Endoplasmic reticulum; Glycoprotein; Golgi apparatus;
KW Membrane; Reference proteome; Sugar transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..327
FT /note="GDP-mannose transporter"
FT /id="PRO_0000333535"
FT TOPO_DOM 1..4
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 5..25
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 26..36
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 58..78
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 79..93
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 94..102
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 103..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 126..131
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 132..149
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 150..163
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 185..207
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 208..228
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 229..238
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..266
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 267..289
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..292
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 293..312
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 313..327
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT CARBOHYD 158
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 234
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 327 AA; 35766 MW; 19C1FE46F893551E CRC64;
MESSLAAIAN SGPISIFSYC VSSILMTVTN KYVLSGFSFN MNFLLLAVQS IVCIVTIGSL
KSFGVITYRQ FNKEEARKWS PIAVLLVIMI YTSSKALQYL SIPVYTIFKN LTIILIAYGE
VLWFGGKVTT MALSSFLLMV FSSVVAWYGD EAVSGSGNES FIALYLGYFW MATNCFASAA
FVLIMRKRIK LTNFKDFDTM YYNNLLSIPI LLASSIIFED WSAENLAVNF PSDNRTATIA
AMVLSGASSV GISYCSAWCV RVTSSTTYSM VGALNKLPIA LSGLVFFPAA VNFWSVASIF
VGFAAGLVYA VAKQRQQKEN VSLPSSK
