GMT_SCHPO
ID GMT_SCHPO Reviewed; 345 AA.
AC Q9UTK8;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 116.
DE RecName: Full=GDP-mannose transporter;
DE Short=GMT;
GN Name=vrg4; ORFNames=SPAC144.18;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1] {ECO:0000312|EMBL:CAB59698.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Involved in the import of GDP-mannose from the cytoplasm into
CC the Golgi lumen. {ECO:0000250}.
CC -!- SUBUNIT: Homooligomer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic
CC reticulum membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TPT transporter family. SLC35D subfamily.
CC {ECO:0000255}.
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DR EMBL; CU329670; CAB59698.1; -; Genomic_DNA.
DR PIR; T37685; T37685.
DR RefSeq; NP_594679.1; NM_001020108.2.
DR AlphaFoldDB; Q9UTK8; -.
DR SMR; Q9UTK8; -.
DR BioGRID; 279296; 3.
DR STRING; 4896.SPAC144.18.1; -.
DR iPTMnet; Q9UTK8; -.
DR MaxQB; Q9UTK8; -.
DR PaxDb; Q9UTK8; -.
DR EnsemblFungi; SPAC144.18.1; SPAC144.18.1:pep; SPAC144.18.
DR GeneID; 2542850; -.
DR KEGG; spo:SPAC144.18; -.
DR PomBase; SPAC144.18; vrg4.
DR VEuPathDB; FungiDB:SPAC144.18; -.
DR eggNOG; KOG1444; Eukaryota.
DR HOGENOM; CLU_025360_1_2_1; -.
DR InParanoid; Q9UTK8; -.
DR OMA; IQSTVCV; -.
DR PhylomeDB; Q9UTK8; -.
DR PRO; PR:Q9UTK8; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IDA:PomBase.
DR GO; GO:0000139; C:Golgi membrane; EXP:PomBase.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
DR GO; GO:0005458; F:GDP-mannose transmembrane transporter activity; IMP:PomBase.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:1990570; P:GDP-mannose transmembrane transport; IMP:PomBase.
DR InterPro; IPR038736; Vrg4-like.
DR PANTHER; PTHR11132:SF251; PTHR11132:SF251; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle; Endoplasmic reticulum; Golgi apparatus; Membrane;
KW Reference proteome; Sugar transport; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..345
FT /note="GDP-mannose transporter"
FT /id="PRO_0000315880"
FT TOPO_DOM 1..8
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 30..40
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 62..78
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 79..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 102..104
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 105..127
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 128..131
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 132..150
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 151..161
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 183..194
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 195..215
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 216..233
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 255..264
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 265..285
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 286..288
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 289..309
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 310..345
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT REGION 319..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 345 AA; 38019 MW; 0F2498A81C23629C CRC64;
MDNHMLNRIS KSPILPVVSY CMASILMTLT NKYVLSSPGY NMNFLLLTVQ STVCVAAIGI
LKRLKVINYR DFDFREAKFW FPISFLLVAM IYTASKALQF LSVPVYTIFK NLTIIIIAYG
EVLWFGGHVT ALTLFSFGLM VLSSIVAAWA DIQSSSFASQ TLNSGYLWMV LNCLTNAAFV
LAMRKRIKLT NFRDFDTMFY NNLLSIPVLV ICTLFTEDWS AENIAQNFPP DAKFGVLMAM
AISGVSSVGI SYTSAWCVRV TSSTTYSMVG ALNKLPLAIA GLVFFDAPIT FGSVTAILLG
FISGVVYAVA KSQQQRQKDP ATILPMTHNP VSASSQSMRD SLSKS
