GMT_YARLI
ID GMT_YARLI Reviewed; 326 AA.
AC Q6C0U0;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 25-MAY-2022, entry version 90.
DE RecName: Full=GDP-mannose transporter;
DE Short=GMT;
GN Name=VRG4; OrderedLocusNames=YALI0F21791g;
OS Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Dipodascaceae; Yarrowia.
OX NCBI_TaxID=284591;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLIB 122 / E 150;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Involved in the import of GDP-mannose from the cytoplasm into
CC the Golgi lumen. {ECO:0000250}.
CC -!- SUBUNIT: Homooligomer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic
CC reticulum membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TPT transporter family. SLC35D subfamily.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CR382132; CAG78533.1; -; Genomic_DNA.
DR RefSeq; XP_505722.1; XM_505722.1.
DR AlphaFoldDB; Q6C0U0; -.
DR SMR; Q6C0U0; -.
DR STRING; 4952.CAG78533; -.
DR EnsemblFungi; CAG78533; CAG78533; YALI0_F21791g.
DR GeneID; 2908843; -.
DR KEGG; yli:YALI0F21791g; -.
DR VEuPathDB; FungiDB:YALI0_F21791g; -.
DR HOGENOM; CLU_025360_1_2_1; -.
DR InParanoid; Q6C0U0; -.
DR OMA; IQSTVCV; -.
DR Proteomes; UP000001300; Chromosome F.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
DR GO; GO:0005458; F:GDP-mannose transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR InterPro; IPR038736; Vrg4-like.
DR PANTHER; PTHR11132:SF251; PTHR11132:SF251; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle; Endoplasmic reticulum; Golgi apparatus; Membrane;
KW Reference proteome; Sugar transport; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..326
FT /note="GDP-mannose transporter"
FT /id="PRO_0000333540"
FT TOPO_DOM 1..4
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 5..25
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 26..35
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 57..74
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 75..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 98..100
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 101..123
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 124..129
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 130..152
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 153..163
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 185..208
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 209..229
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 230..237
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 238..258
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..268
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 269..289
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..291
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 292..312
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 313..326
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
SQ SEQUENCE 326 AA; 35155 MW; B50FA996BB36EDB0 CRC64;
MEKSITNSPV LSILSYCAAS ILMTVTNKYV LSGTSFNLNL ALLAVQSIVC LTAISIGKSF
GLCKFRSFNA DEAKKWFPIA LLLVVMIYTS SKALQFLSIP VYTIFKNLTI ILIAYGEVLW
FGGSVTSMAL ASFVLMVLSS VIAAWSDISG AIAVSGSATT TVTALNIGYF WMMSNCFASA
AFVLYMRKRI KLTNFGDFDT TFYNNLLSIP VLLIASLLFE DWSPANLAVN FPPESRNLIF
FSMVVSGLMS IGISYCSAWC VRVTSSTTYS MVGALNKLPL ALSGIVFFGT PATFSSVSAI
FVGFVAGIVY AVAQIQKKKA EAALPK
