ID   GMUR_BACSU              Reviewed;         237 AA.
AC   O05509; Q797D8;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=HTH-type transcriptional regulator GmuR;
DE   AltName: Full=Glucomannan utilization operon repressor;
DE   AltName: Full=Glucomannan utilization protein R;
GN   Name=gmuR; Synonyms=ydhQ; OrderedLocusNames=BSU05850;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168 / JH642;
RX   PubMed=9202461; DOI=10.1099/00221287-143-6-1861;
RA   Sadaie Y., Yata K., Fujita M., Sagai H., Itaya M., Kasahara Y.,
RA   Ogasawara N.;
RT   "Nucleotide sequence and analysis of the phoB-rrnE-groESL region of the
RT   Bacillus subtilis chromosome.";
RL   Microbiology 143:1861-1866(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   INDUCTION, AND FUNCTION AS A REPRESSOR OF GLUCOMANNAN UTILIZATION OPERON.
RC   STRAIN=168;
RX   PubMed=18177310; DOI=10.1111/j.1574-6968.2007.01018.x;
RA   Sadaie Y., Nakadate H., Fukui R., Yee L.M., Asai K.;
RT   "Glucomannan utilization operon of Bacillus subtilis.";
RL   FEMS Microbiol. Lett. 279:103-109(2008).
CC   -!- FUNCTION: Transcriptional repressor of the gmuBACDREFG operon which is
CC       involved in the uptake and degradation of glucomannan.
CC       {ECO:0000269|PubMed:18177310}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- INDUCTION: Up-regulated by konjac glucomannan and by cellobiose and
CC       mannobiose, the possible degradation products of glucomannan. Repressed
CC       by glucose via the carbon catabolite repression system.
CC       {ECO:0000269|PubMed:18177310}.
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DR   EMBL; D88802; BAA19709.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB12404.1; -; Genomic_DNA.
DR   PIR; E69785; E69785.
DR   RefSeq; NP_388466.1; NC_000964.3.
DR   RefSeq; WP_003234096.1; NZ_JNCM01000031.1.
DR   AlphaFoldDB; O05509; -.
DR   SMR; O05509; -.
DR   STRING; 224308.BSU05850; -.
DR   PaxDb; O05509; -.
DR   PRIDE; O05509; -.
DR   EnsemblBacteria; CAB12404; CAB12404; BSU_05850.
DR   GeneID; 939879; -.
DR   KEGG; bsu:BSU05850; -.
DR   PATRIC; fig|224308.179.peg.629; -.
DR   eggNOG; COG2188; Bacteria.
DR   InParanoid; O05509; -.
DR   OMA; RMTMKRA; -.
DR   PhylomeDB; O05509; -.
DR   BioCyc; BSUB:BSU05850-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR   CDD; cd07377; WHTH_GntR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.40.1410.10; -; 1.
DR   InterPro; IPR028978; Chorismate_lyase_/UTRA_dom_sf.
DR   InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR   InterPro; IPR011663; UTRA.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00392; GntR; 1.
DR   Pfam; PF07702; UTRA; 1.
DR   PRINTS; PR00035; HTHGNTR.
DR   SMART; SM00345; HTH_GNTR; 1.
DR   SMART; SM00866; UTRA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF64288; SSF64288; 1.
DR   PROSITE; PS50949; HTH_GNTR; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..237
FT                   /note="HTH-type transcriptional regulator GmuR"
FT                   /id="PRO_0000360727"
FT   DOMAIN          1..69
FT                   /note="HTH gntR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
FT   DNA_BIND        29..48
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
SQ   SEQUENCE   237 AA;  27374 MW;  B5025AECA4C5B8E7 CRC64;
     MNKYEIIANE MRNRIKNNVY PIDQPIPDEV SLAKEFNSSR MTMKRALDNL VAEGLLFRKR
     GHGTFIIQSA IQDDHVHVVS NEILGLTNLL KDKKIKSKVI QFEVQFPTEE VAAHLSIDQK
     TPVYYVVRLR IVEGEPYVLE KTYMPTHLIP GINDDVLHDS IYNHITNVLQ LKIAGTHRKI
     RACKSDHIDQ QHLGCKQDDP ILEVEHVGFL DTGIPFEYSF SRHRHDKFVV TSVNIRR