GM_EHV1B
ID GM_EHV1B Reviewed; 450 AA.
AC P28948; Q6DLF9;
DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-1992, sequence version 1.
DT 23-FEB-2022, entry version 90.
DE RecName: Full=Envelope glycoprotein M {ECO:0000255|HAMAP-Rule:MF_04035};
DE Short=gM {ECO:0000255|HAMAP-Rule:MF_04035};
GN Name=gM {ECO:0000255|HAMAP-Rule:MF_04035}; OrderedLocusNames=52;
OS Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX NCBI_TaxID=31520;
OH NCBI_TaxID=9796; Equus caballus (Horse).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=1318606; DOI=10.1016/0042-6822(92)90706-u;
RA Telford E.A.R., Watson M.S., McBride K., Davison A.J.;
RT "The DNA sequence of equine herpesvirus-1.";
RL Virology 189:304-316(1992).
RN [2]
RP FUNCTION.
RC STRAIN=RacL11;
RX PubMed=8648751; DOI=10.1128/jvi.70.6.4110-4115.1996;
RA Osterrieder N., Neubauer A., Brandmueller C., Braun B., Kaaden O.-R.,
RA Baines J.D.;
RT "The equine herpesvirus 1 glycoprotein gp21/22a, the herpes simplex virus
RT type 1 gM homolog, is involved in virus penetration and cell-to-cell spread
RT of virions.";
RL J. Virol. 70:4110-4115(1996).
RN [3]
RP SUBUNIT, AND SUBCELLULAR LOCATION.
RX PubMed=11861861; DOI=10.1128/jvi.76.6.2952-2963.2002;
RA Rudolph J., Seyboldt C., Granzow H., Osterrieder N.;
RT "The gene 10 (UL49.5) product of equine herpesvirus 1 is necessary and
RT sufficient for functional processing of glycoprotein M.";
RL J. Virol. 76:2952-2963(2002).
CC -!- FUNCTION: Envelope glycoprotein important for virion assembly and
CC egress. Plays a role in the correct incorporation of gH-gL into virion
CC membrane. Directs the glycoprotein N (gN) to the host trans-Golgi
CC network. {ECO:0000255|HAMAP-Rule:MF_04035, ECO:0000269|PubMed:8648751}.
CC -!- SUBUNIT: Interacts (via N-terminus) with gN (via N-terminus). The gM-gN
CC heterodimer forms the gCII complex. {ECO:0000255|HAMAP-Rule:MF_04035}.
CC -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000255|HAMAP-
CC Rule:MF_04035}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_04035}. Host Golgi apparatus, host trans-Golgi network
CC {ECO:0000255|HAMAP-Rule:MF_04035}. Host endosome membrane
CC {ECO:0000255|HAMAP-Rule:MF_04035}; Multi-pass membrane protein
CC {ECO:0000255|HAMAP-Rule:MF_04035}. Host nucleus inner membrane
CC {ECO:0000255|HAMAP-Rule:MF_04035}; Multi-pass membrane protein
CC {ECO:0000255|HAMAP-Rule:MF_04035}. Note=During virion morphogenesis,
CC this protein accumulates in the trans-Golgi network where secondary
CC envelopment occurs. {ECO:0000255|HAMAP-Rule:MF_04035}.
CC -!- SIMILARITY: Belongs to the herpesviridae glycoprotein M family.
CC {ECO:0000255|HAMAP-Rule:MF_04035}.
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DR EMBL; AY665713; AAT67309.1; -; Genomic_DNA.
DR PIR; G36800; WZBEE4.
DR RefSeq; YP_053096.1; NC_001491.2.
DR SMR; P28948; -.
DR PRIDE; P28948; -.
DR GeneID; 2948556; -.
DR KEGG; vg:2948556; -.
DR Proteomes; UP000001189; Genome.
DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0044201; C:host cell nuclear inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-UniRule.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR HAMAP; MF_04035; HSV_GM; 1.
DR InterPro; IPR000785; Herpes_glycop_M.
DR Pfam; PF01528; Herpes_glycop; 1.
DR PRINTS; PR00333; HSVINTEGRLMP.
PE 1: Evidence at protein level;
KW Disulfide bond; Glycoprotein; Host endosome; Host Golgi apparatus;
KW Host membrane; Host nucleus; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Viral envelope protein; Virion.
FT CHAIN 1..450
FT /note="Envelope glycoprotein M"
FT /id="PRO_0000115777"
FT TOPO_DOM 1..31
FT /note="Intravirion"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04035"
FT TRANSMEM 32..52
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04035"
FT TOPO_DOM 53..101
FT /note="Virion surface"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04035"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04035"
FT TOPO_DOM 123..153
FT /note="Intravirion"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04035"
FT TRANSMEM 154..174
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04035"
FT TOPO_DOM 175..178
FT /note="Virion surface"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04035"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04035"
FT TOPO_DOM 200..236
FT /note="Intravirion"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04035"
FT TRANSMEM 237..257
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04035"
FT TOPO_DOM 258..270
FT /note="Virion surface"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04035"
FT TRANSMEM 271..291
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04035"
FT TOPO_DOM 292..294
FT /note="Intravirion"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04035"
FT TRANSMEM 295..315
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04035"
FT TOPO_DOM 316..334
FT /note="Virion surface"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04035"
FT TRANSMEM 335..355
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04035"
FT TOPO_DOM 356..450
FT /note="Intravirion"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04035"
FT DISULFID 63
FT /note="Interchain (with gN)"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04035"
SQ SEQUENCE 450 AA; 49221 MW; 5F1271CBEDA9B0E6 CRC64;
MARRGAAVAE EPLLPSSGIV GIGPIEGINW RTWLVQVFCF ALTTSVLFIT LVTASLPQTG
YPCFYGSLVD YTQKNHSVVD GVWMRQIAGG VAPTLFLETT SLVAFLYYTT LVLVAISFYL
IISAVLVRRY ARGKECTAVA GCTRPTTTLI ASHVTLVLGT LATWLLQVVI LLLSHKQAVL
GAAVYVVHFV SLVFFCMSFS GLGTASAQYS SNLRILKTNL PALHKMAGPG RAVMTNLGMG
MLGISLPILS LMLGIILANS FHITLWQTVT VAVGVFVALG LMFLIIVELI VSHYVHVLVG
PALAVLVASS TLAVATHSYF VHFHAMVSVQ APNLATASKA IVGIMAVISI IMLVVRLVRA
IMFHKKRNTE FYGRVKTVSS KARRYANKVR GPRRNPQPLN VAESRGMLLA EDSETDAEEP
IYDVVSEEFE TEYYDDPQRV PERSHRREYR
