ID   GNGF_STRP1              Reviewed;         325 AA.
AC   Q9A0R7; Q48ZR0;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 122.
DE   RecName: Full=Putative gluconeogenesis factor {ECO:0000255|HAMAP-Rule:MF_00973};
GN   OrderedLocusNames=SPy_0653, M5005_Spy0540;
OS   Streptococcus pyogenes serotype M1.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=301447;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700294 / SF370 / Serotype M1;
RX   PubMed=11296296; DOI=10.1073/pnas.071559398;
RA   Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K.,
RA   Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P.,
RA   Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X.,
RA   Clifton S.W., Roe B.A., McLaughlin R.E.;
RT   "Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-947 / MGAS5005 / Serotype M1;
RX   PubMed=16088826; DOI=10.1086/432514;
RA   Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K.,
RA   Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P.,
RA   Musser J.M.;
RT   "Evolutionary origin and emergence of a highly successful clone of serotype
RT   M1 group A Streptococcus involved multiple horizontal gene transfer
RT   events.";
RL   J. Infect. Dis. 192:771-782(2005).
CC   -!- FUNCTION: Required for morphogenesis under gluconeogenic growth
CC       conditions. {ECO:0000255|HAMAP-Rule:MF_00973}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00973}.
CC   -!- SIMILARITY: Belongs to the gluconeogenesis factor family.
CC       {ECO:0000255|HAMAP-Rule:MF_00973}.
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DR   EMBL; AE004092; AAK33616.1; -; Genomic_DNA.
DR   EMBL; CP000017; AAZ51158.1; -; Genomic_DNA.
DR   RefSeq; NP_268895.1; NC_002737.2.
DR   AlphaFoldDB; Q9A0R7; -.
DR   SMR; Q9A0R7; -.
DR   STRING; 1314.HKU360_00550; -.
DR   PaxDb; Q9A0R7; -.
DR   EnsemblBacteria; AAK33616; AAK33616; SPy_0653.
DR   KEGG; spy:SPy_0653; -.
DR   KEGG; spz:M5005_Spy0540; -.
DR   PATRIC; fig|160490.10.peg.555; -.
DR   HOGENOM; CLU_044041_0_1_9; -.
DR   OMA; LCGDDDW; -.
DR   Proteomes; UP000000750; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0043743; F:LPPG:FO 2-phospho-L-lactate transferase activity; IEA:InterPro.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.10680; -; 1.
DR   HAMAP; MF_00973; Gluconeogen_factor; 1.
DR   InterPro; IPR002882; CofD.
DR   InterPro; IPR038136; CofD-like_dom_sf.
DR   InterPro; IPR010119; Gluconeogen_factor.
DR   PANTHER; PTHR30135; PTHR30135; 1.
DR   Pfam; PF01933; CofD; 1.
DR   SUPFAM; SSF142338; SSF142338; 1.
DR   TIGRFAMs; TIGR01826; CofD_related; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..325
FT                   /note="Putative gluconeogenesis factor"
FT                   /id="PRO_0000107814"
SQ   SEQUENCE   325 AA;  35706 MW;  CD3D34A9FDDBC779 CRC64;
     MKNPKMTVIG GGTGISIILK SLRNEAVDIT AVVTVADDGG SSGELRNAMQ LAPPGDLRNV
     LLAMSDMPKF YERVFQYRFN ESDGALAGHP LGNLIIAGIS EMQGSTYNAI QILTKFFHIT
     GKIYPSSEQA LTLHAVFKDG HEVAGESSIA KYPGMIDHVY VTNTYNDQKP QASRKVVEAI
     LESDMIVLGP GSLFTSILPN LVIPEIKEAL RQTKAEVVYI CNIMTQYGET EQFSDADHVA
     VLNQHLGRDL IDTVLVNVAK VPQAYMNSNK FDEYLVQVDH DFAGLCRAAK RVISSYFLRL
     ENGGAFHDGN LVVEELMNLV RIVKQ