ID   GNL3L_ENCCU             Reviewed;         313 AA.
AC   Q8SUT1;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2013, sequence version 2.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Guanine nucleotide-binding protein-like 3-like protein;
GN   OrderedLocusNames=ECU08_0330;
OS   Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC   Encephalitozoon.
OX   NCBI_TaxID=284813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GB-M1;
RX   PubMed=11719806; DOI=10.1038/35106579;
RA   Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F.,
RA   Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P.,
RA   Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J.,
RA   Vivares C.P.;
RT   "Genome sequence and gene compaction of the eukaryote parasite
RT   Encephalitozoon cuniculi.";
RL   Nature 414:450-453(2001).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=GB-M1;
RX   PubMed=20003517; DOI=10.1186/1471-2164-10-607;
RA   Peyretaillade E., Goncalves O., Terrat S., Dugat-Bony E., Wincker P.,
RA   Cornman R.S., Evans J.D., Delbac F., Peyret P.;
RT   "Identification of transcriptional signals in Encephalitozoon cuniculi
RT   widespread among Microsporidia phylum: support for accurate structural
RT   genome annotation.";
RL   BMC Genomics 10:607-607(2009).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], DEVELOPMENTAL
RP   STAGE, AND SUBCELLULAR LOCATION.
RX   PubMed=16691553; DOI=10.1002/pmic.200500796;
RA   Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.;
RT   "Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi
RT   (microsporidia): a reference map for proteins expressed in late sporogonial
RT   stages.";
RL   Proteomics 6:3625-3635(2006).
CC   -!- FUNCTION: Required for normal processing of ribosomal pre-rRNA.
CC       Required for cell proliferation. Binds GTP (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in late sporogonial stages.
CC       {ECO:0000269|PubMed:16691553}.
CC   -!- SIMILARITY: Belongs to the MMR1/HSR1 GTP-binding protein family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL590448; CAD26338.2; -; Genomic_DNA.
DR   RefSeq; NP_597162.1; NM_001041771.1.
DR   AlphaFoldDB; Q8SUT1; -.
DR   SMR; Q8SUT1; -.
DR   STRING; 284813.Q8SUT1; -.
DR   GeneID; 859584; -.
DR   KEGG; ecu:ECU08_0330; -.
DR   VEuPathDB; MicrosporidiaDB:ECU08_0330; -.
DR   HOGENOM; CLU_891658_0_0_1; -.
DR   InParanoid; Q8SUT1; -.
DR   OrthoDB; 1171110at2759; -.
DR   Proteomes; UP000000819; Chromosome VIII.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   1: Evidence at protein level;
KW   GTP-binding; Nucleotide-binding; Nucleus; Reference proteome;
KW   Ribosome biogenesis.
FT   CHAIN           1..313
FT                   /note="Guanine nucleotide-binding protein-like 3-like
FT                   protein"
FT                   /id="PRO_0000383044"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         95..98
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
FT   BINDING         178..185
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
FT   BINDING         212..215
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   313 AA;  36437 MW;  727E3EC3E0DEFB05 CRC64;
     MGIKKKRQSK RLTTRKREGM LKRARANERK KRRMDRKMQA KVERIPPSVL RTDEENMQYA
     EIKRMAKLRK MEYDEALRNS EKKEAYLDGI LRLVSKSDVV IEVIDARDPD SSRNSEAEKI
     VSEHGKKLIM VLNYTQYVPR EVVDEWKVHL KRDGNDCIEV TEEDMRQIGK ETRIGIFGNP
     GSGKNFVLRG ISRILEEKPN SVVVSVPLSK VTLSSILRGC HGLMGIAFRD YIEAIVKRID
     RGEVSLRHGI PEFSNAEELL ESICDVHGIR DESRSVCYMK ASERFLEDFL RHKILFWRRV
     YSDENDLSFA FCQ