GNL3_DANRE
ID GNL3_DANRE Reviewed; 561 AA.
AC Q6DRP2; Q6DI18;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Guanine nucleotide-binding protein-like 3;
DE AltName: Full=Nucleostemin-like protein;
GN Name=gnl3;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15256591; DOI=10.1073/pnas.0403929101;
RA Amsterdam A., Nissen R.M., Sun Z., Swindell E.C., Farrington S.,
RA Hopkins N.;
RT "Identification of 315 genes essential for early zebrafish development.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:12792-12797(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-524.
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May play a role in regulating cellular proliferation.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q811S9}. Nucleus,
CC nucleolus {ECO:0000250|UniProtKB:Q811S9}. Note=Shuttles between the
CC nucleus and nucleolus. {ECO:0000250|UniProtKB:Q811S9}.
CC -!- DOMAIN: In contrast to other GTP-binding proteins, this family is
CC characterized by a circular permutation of the GTPase motifs described
CC by a G4-G1-G3 pattern.
CC -!- SIMILARITY: Belongs to the TRAFAC class YlqF/YawG GTPase family.
CC {ECO:0000255|PROSITE-ProRule:PRU01058}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH75773.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
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DR EMBL; AY648717; AAT68035.1; -; mRNA.
DR EMBL; BC075773; AAH75773.1; ALT_SEQ; mRNA.
DR RefSeq; NP_001002297.1; NM_001002297.1.
DR AlphaFoldDB; Q6DRP2; -.
DR SMR; Q6DRP2; -.
DR STRING; 7955.ENSDARP00000109517; -.
DR PaxDb; Q6DRP2; -.
DR GeneID; 321897; -.
DR KEGG; dre:321897; -.
DR CTD; 26354; -.
DR ZFIN; ZDB-GENE-030131-616; gnl3.
DR eggNOG; KOG2484; Eukaryota.
DR InParanoid; Q6DRP2; -.
DR OrthoDB; 1210675at2759; -.
DR PhylomeDB; Q6DRP2; -.
DR Reactome; R-DRE-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR PRO; PR:Q6DRP2; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005525; F:GTP binding; ISS:UniProtKB.
DR GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:ZFIN.
DR GO; GO:0003407; P:neural retina development; IMP:ZFIN.
DR GO; GO:0042127; P:regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:0007096; P:regulation of exit from mitosis; IMP:ZFIN.
DR GO; GO:0045664; P:regulation of neuron differentiation; IMP:ZFIN.
DR Gene3D; 1.10.1580.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR030378; G_CP_dom.
DR InterPro; IPR014813; Gnl3_N_dom.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR023179; GTP-bd_ortho_bundle_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF08701; GN3L_Grn1; 1.
DR Pfam; PF01926; MMR_HSR1; 1.
DR PRINTS; PR00326; GTP1OBG.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51721; G_CP; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; GTP-binding; Nucleotide-binding; Nucleus; Reference proteome.
FT CHAIN 1..561
FT /note="Guanine nucleotide-binding protein-like 3"
FT /id="PRO_0000122447"
FT DOMAIN 133..319
FT /note="CP-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01058"
FT REGION 28..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 76..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 486..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 53..98
FT /evidence="ECO:0000255"
FT COMPBIAS 486..504
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 181..184
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255"
FT BINDING 268..275
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255"
FT BINDING 312..315
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255"
FT CONFLICT 166
FT /note="M -> I (in Ref. 2; AAH75773)"
FT /evidence="ECO:0000305"
FT CONFLICT 197
FT /note="F -> Y (in Ref. 2; AAH75773)"
FT /evidence="ECO:0000305"
FT CONFLICT 281
FT /note="L -> M (in Ref. 2; AAH75773)"
FT /evidence="ECO:0000305"
FT CONFLICT 357
FT /note="V -> I (in Ref. 2; AAH75773)"
FT /evidence="ECO:0000305"
FT CONFLICT 380
FT /note="H -> R (in Ref. 2; AAH75773)"
FT /evidence="ECO:0000305"
FT CONFLICT 421
FT /note="S -> F (in Ref. 2; AAH75773)"
FT /evidence="ECO:0000305"
FT CONFLICT 481
FT /note="I -> T (in Ref. 2; AAH75773)"
FT /evidence="ECO:0000305"
FT CONFLICT 485
FT /note="A -> T (in Ref. 2; AAH75773)"
FT /evidence="ECO:0000305"
FT CONFLICT 497
FT /note="D -> E (in Ref. 2; AAH75773)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 561 AA; 62901 MW; 278839D635246282 CRC64;
MKRPKLKKAS KRLSCAKRYK IQKKVREHNR KLKKAAKKQG ISRKAKKDIG VPNSAPFKEE
VLREAEQRKQ ELETLKEQNK IVKQQEKAAK RKKEKDAASS VKEPAAKKAK KAAKIKEARA
AIVKVKSAKT FKCQELNKVI EASDVIVEVL DARDPLGCRC PQLEEMVLKH EGKKKLLFIL
NKIDLVPKDN LEKWLHFLEA ECPTFLFKSS MQLKDRTVQQ KRQQRGTNAV LDHSRAASCF
GKDFLLQTLN DLANKKEGET MLKVGVVGFP NVGKSSIINS LKEMRACNAG VQRGLTRCMQ
EVHITKKVKM IDSPGILAAL SNPGSAMALR SLQVEEKEES PQEAVRNLLK QCNQQHVMLQ
YNVPDYRSSL EFLTTFAMKH GLLQKGGVAD TELAATTFLN DWTGAKLSYY SRVPERQGLP
SYLSDAIVTE LQSDVDMDAV KKGNENVKRS VRFPNLASCI SFDSSGPTAG VLDVSELPKE
ILTKAATTTD AEEEKMDTTT NTDEPEAESH ISSTVEPIQE PTEKRKDKPA KEVKFVPVNT
DLTSMQNKNN EDAYDFNTDF V
