ID   GNL3_XENLA              Reviewed;         542 AA.
AC   Q7ZX41;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Guanine nucleotide-binding protein-like 3;
DE   AltName: Full=Nucleostemin-like protein;
GN   Name=gnl3;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in regulating cellular proliferation.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q811S9}. Nucleus,
CC       nucleolus {ECO:0000250|UniProtKB:Q811S9}. Note=Shuttles between the
CC       nucleus and nucleolus. {ECO:0000250|UniProtKB:Q811S9}.
CC   -!- DOMAIN: In contrast to other GTP-binding proteins, this family is
CC       characterized by a circular permutation of the GTPase motifs described
CC       by a G4-G1-G3 pattern.
CC   -!- SIMILARITY: Belongs to the TRAFAC class YlqF/YawG GTPase family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01058}.
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DR   EMBL; BC045248; AAH45248.1; -; mRNA.
DR   RefSeq; NP_001080648.1; NM_001087179.1.
DR   AlphaFoldDB; Q7ZX41; -.
DR   SMR; Q7ZX41; -.
DR   BioGRID; 98582; 1.
DR   IntAct; Q7ZX41; 1.
DR   DNASU; 380340; -.
DR   GeneID; 380340; -.
DR   KEGG; xla:380340; -.
DR   CTD; 380340; -.
DR   Xenbase; XB-GENE-6253784; gnl3.L.
DR   OrthoDB; 1210675at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 380340; Expressed in neurula embryo and 19 other tissues.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005525; F:GTP binding; ISS:UniProtKB.
DR   GO; GO:0042127; P:regulation of cell population proliferation; ISS:UniProtKB.
DR   Gene3D; 1.10.1580.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR030378; G_CP_dom.
DR   InterPro; IPR014813; Gnl3_N_dom.
DR   InterPro; IPR006073; GTP-bd.
DR   InterPro; IPR023179; GTP-bd_ortho_bundle_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF08701; GN3L_Grn1; 1.
DR   Pfam; PF01926; MMR_HSR1; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51721; G_CP; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; GTP-binding; Nucleotide-binding; Nucleus; Reference proteome.
FT   CHAIN           1..542
FT                   /note="Guanine nucleotide-binding protein-like 3"
FT                   /id="PRO_0000122448"
FT   DOMAIN          124..305
FT                   /note="CP-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01058"
FT   REGION          1..119
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          472..542
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          56..114
FT                   /evidence="ECO:0000255"
FT   COILED          467..515
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..44
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        68..119
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        472..502
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         171..174
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
FT   BINDING         254..261
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
FT   BINDING         298..301
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   542 AA;  60858 MW;  C3389A0C0C0B64E2 CRC64;
     MKRPKLRKSS KRLSCHKRYK IQKKVREHKR KVKKEAKKSG PRKHKKDITV PNAAPFKAQI
     LQEAQLRRQQ QEELKQKQKL DRQKEVAKKR KLEEKKNNNS EKKEKRDKKR KETKTPDDPD
     VVLCRQVNKV LEQSDVIVEV LDARDPLGSR CSQAEEVVLK SPNKRLLLLL NKSDLVPREM
     VEKWLQVLSA ELPTVPFRCV AQIQDKSEKK KKKKVPVSAD LVTDPKCPGG QVLLKILHSL
     CPSHNEAIKV GVIGFANVGK SSVINSLKQS HVCNVGPSKG TTKFLQEVRL DPQIRLLDSP
     ALLVSPHNPP VALMLRSASE SKVDVLAAVE AILKHCSKQE LMLHYTIADY RNSLECLTLL
     AHRRGMLKKG GVPDTEGAGR LLFNDWMGAR MKYYCRPPDS PVCQPHISRE VVAAMSSGIC
     SEELAMDNAS TLKALKCPNS ANIVVFASVG PTSAIMDETQ LVDPEPELIE EELEENDGEE
     EEDMEEEEDD DEGSEEEEDL EAKSLTQEVT SAKEKDSKSA GPAVSFDQAA DDDTYDFNTD
     FV